Handbook of Analysis of Oligonucleotides and Related Products - Image 1

Price loading...

CRC Press Handbook of Analysis of Oligonucleotides and Related Products

Name: Handbook of Analysis of Oligonucleotides and Related Products
Brand: CRC Press

Pharmacy - Dispensing

Price History & Forecast

No Price Data Available

Price history will appear here once data is collected from Amazon.

Price Distribution

No price data available for histogram

Description

Oligonucleotides represent one of the most significant pharmaceutical breakthroughs in recent years, showing great promise as diagnostic and therapeutic agents for malignant tumors, cardiovascular disease, diabetes, viral infections, and many other degenerative disorders. The Handbook of Analysis of Oligonucleotides and Related Products is an essential reference manual on the practical application of modern and emerging analytical techniques for the analysis of this unique class of compounds. A strong collaboration among thirty leading analytical scientists from around the world, the book provides readers with a comprehensive overview of the most commonly used analytical techniques and their advantages and limitations in assuring the identity, purity, quality, and strength of an oligonucleotide intended for therapeutic use. Topics discussed include: Strategies for enzymatic or chemical degradation of chemically modified oligonucleotides toward mass spectrometric sequencing Purity analysis by chromatographic or electrophoretic methods, including RP-HPLC, AX-HPLC, HILIC, SEC, and CGE Characterization of sequence-related impurities in oligonucleotides by mass spectrometry and chromatography Structure elucidation by spectroscopic methods (IR, NMR, MS) as well as base composition and thermal melt analysis (Tm) Approaches for the accurate determination of molar extinction coefficient of oligonucleotides Accurate determination of assay values Assessment of the overall quality of oligonucleotides, including microbial analysis and determination of residual solvents and heavy metals Strategies for determining the chemical stability of oligonucleotides The use of hybridization techniques for supporting pharmacokinetics and drug metabolism studies in preclinical and clinical development Guidance for the presentation of relevant analytical information towards meeting current regulatory expectations for oligonucleotide therapeutics This resource provides a practical guide for applying state-of-the-art analytical techniques in research, development, and manufacturing settings.

Product Specifications

Brand: CRC Press
Format: hardcover
ASIN: 1439819939
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Allied Health Professions > Pharmacy - Dispensing
Domain: Amazon UK
Release Date: 23 February 2011
Listed Since: 22 June 2009

Barcode

No barcode data available

CRC Press Handbook of Analysis of Oligonucleotides and Related Products

Price History & Forecast

No Price Data Available

Price Distribution

Description

Product Specifications

Barcode

Similar Products You Might Like

Handbook of Analysis of Oligonucleotides and Related Products

Protocols for Oligonucleotides and Analogs: Synthesis and Properties: 20 (Methods in Molecular Biology, 20)

Oligonucleotide-Based Drugs and Therapeutics: Preclinical and Clinical Considerations for Development

Mass Spectrometry of Nucleosides and Nucleic Acids

A Handbook of Bioanalysis and Drug Metabolism

CRC Press - Methods for Studying Nucleic Acid/Drug Interactions

CRC Press Handbook of Nucleic Acid Purification - Science Book

Handbook of Nucleic Acid Purification

Peptide and Protein Drug Analysis

Peptide and Protein Drug Analysis: 101 (Drugs and the Pharmaceutical Sciences)

Handbook of Analysis of Active Compounds in Functional Foods

Humana Protocols for Oligonucleotide Conjugates - Methods Book

Principles and Practice of Bioanalysis

Bioanalytics: Analytical Methods and Concepts in Biochemistry and Molecular Biology

Advances in Chromatographic Techniques for Therapeutic Drug Monitoring

Methods for Studying Nucleic Acid/Drug Interactions

Bioanalytical Aspects in Biological Therapeutics (Wiley on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods)

Handbook of Advanced Chromatography /Mass Spectrometry Techniques

The Nucleic Acid Protocols Handbook

Humana Drug-DNA Interaction Protocols: 613 Book

Chemometrics Applications and Research: QSAR in Medicinal Chemistry

Peptide Nucleic Acids: Methods and Protocols: 208 (Methods in Molecular Biology)

Handbook on Protein Purification: Industry Challenges and Technological Developments (Biochemistry Research Trends)

Handbook of Molecular and Cellular Methods in Biology and Medicine