Wiley Post-Transcriptional: 15 (Modern Cell Biology)

mRNA METABOLISM & POST-TRANSCRIPTIONAL GENE REGULATION Edited by Joe B. Harford and David R. Morris Gene expression is a process that begins with the transcription ofDNA to an RNA messenger (mRNA), which is then translated into aprotein. Historically, attention has been focused on the regulationof RNA synthesis (transcription); however, there is a growingrecognition of and appreciation for the importance of the manyregulatory mechanisms that take place after RNA synthesis has beencompleted. mRNA Metabolism and Post-Transcriptional Gene Regulation is thefirst comprehensive overview of the various modes of generegulation that exist post-transcriptionally. Collecting studies bysome of the top researchers in the field, this volume provides bothan up-to-date review of the complex "life" of an mRNA molecule andan introduction to current work on the diversity of mechanisms ofpost-transcriptional reactions. Topics covered include: * RNA structure * Mammalian RNA editing * RNA export from the nucleus * The fundamentals of translation initiation * Control of mRNA decay in plants * mRNA metabolism and cancer * Control of mRNA stability during herpes simplex virus infection * Regulation of mRNA expression in HIV-1 and other complexretroviruses * Nucleases * RNA localization A timely contribution to the understanding of genetic regulatorymechanisms, mRNA Metabolism and Post-Transcriptional GeneRegulation provides a basis from which potential therapeuticstrategies may be developed. This book will be of vital interest tocell and molecular biologists at all levels, from graduate studentsto senior investigators, clinical researchers, and professionals inthe pharmaceutical and biotechnology industries. From the Inside Flap mRNA METABOLISM & POST-TRANSCRIPTIONAL GENE REGULATION Edited by Joe B. Harford and David R. Morris Gene expression is a process that begins with the transcription of DNA to an RNA messenger (mRNA), which is then translated into a protein. Historically, attention has been focused on the regulation of RNA synthesis (transcription); however, there is a growing recognition of and appreciation for the importance of the many regulatory mechanisms that take place after RNA synthesis has been completed. mRNA Metabolism and Post-Transcriptional Gene Regulation is the first comprehensive overview of the various modes of gene regulation that exist post-transcriptionally. Collecting studies by some of the top researchers in the field, this volume provides both an up-to-date review of the complex "life" of an mRNA molecule and an introduction to current work on the diversity of mechanisms of post-transcriptional reactions. Topics covered include: RNA structure Mammalian RNA editing RNA export from the nucleus The fundamentals of translation initiation Control of mRNA decay in plants mRNA metabolism and cancer Control of mRNA stability during herpes simplex virus infection Regulation of mRNA expression in HIV-1 and other complex retroviruses Nucleases RNA localization A timely contribution to the understanding of genetic regulatory mechanisms, mRNA Metabolism and Post-Transcriptional Gene Regulation provides a basis from which potential therapeutic strategies may be developed. This book will be of vital interest to cell and molecular biologists at all levels, from graduate students to senior investigators, clinical researchers, and professionals in the pharmaceutical and biotechnology industries. From the Back Cover mRNA METABOLISM & POST-TRANSCRIPTIONAL GENE REGULATION Edited by Joe B. Harford and David R. Morris Gene expression is a process that begins with the transcription of DNA to an RNA messenger (mRNA), which is then translated into a protein. Historically, attention has been focused on the regulation of RNA synthesis (transcription); however, there is a growing recognition of and appreciation for the importance of the many regulatory mechanisms that take place after RNA synthesi