Academic Press Structural Studies of Amyloid-Forming Peptides: Volume 729 (Methods in Enzymology, Volume 729)

Structural Study of Amyloid-β, Volume 729 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on important topics such as the Extraction of Amyloids from Neurodegenerative Disease Tissues for Structural Analysis, Cryo-EM Structure Determination of Amyloid Fibrils: Methodology, Insights, and Practical Tools, Methods for studying molecular architecture of Ab aggregates in tissues using cryo-ET, Cryo-EM methods to study binding between amyloid fibrils and chemical compounds or ligan, Dynamics studies of side-chains and hydration shells in amyloid-beta fibrils using deuterium and oxygen-17 solid-state NMR, and much more. Additional chapters cover the Technical aspects of pressure jump NMR applied to the study of Abeta and protein oligomerization, Characterizations of the beta-amyloid-membrane interaction intermediates, Time-resolved solid-state NMR studies of oligomer formation, Methods for characterizing the individual filament structures of amyloid peptide assemblies using atomic force microscopy, Single-molecule fluorescence spectroscopy and imaging on heterogeneous amyloid beta aggregation, Two-dimensional FT-IR methods on amyloid aggregation and folding pathways, and much more. Provides the latest information on the Structural Study of Amyloid-β Offers outstanding and original reviews on a range of Enzymology topics Serves as an indispensable reference for researchers and students alike