CRC Press Antifungal Therapy, Second Edition

This new edition of Antifungal Therapy aims at providing concise, practical, need-to-know information for busy physicians dealing with fungal infections, such as infectious disease physicians, transplant surgeons, dermatologists, and intensivists, as well as basic scientists and pharmaceutical company researchers interested in the state of antifungal therapy. It provides a comprehensive, up-to-date overview of the pertinent issues pertaining to antifungal treatment including the basics of clinical mycology, management insights for various infections, evidence-based treatment recommendations, and helpful tables summarizing currently available pharmacokinetics data.Key Features• Features useful information on administration, dosage and pharmacology of antifungal drugs that can be difficult to use in clinical practice• Contains common Clinical Questions & Answers to highlight frequently encountered patient issues• Covers clinical mycology essentials in addition to antifungal treatment to create a well-rounded reference• Presents illustrations and clinical photos in full color to elucidate the concepts• Provides detailed evidence of treatment recommendations Review "This book succeeds overall as an important reference and a comprehensive review of the current state of antifungal therapy in humans. The up-to-date information makes it a useful resource for clinicians consulting for immunosuppressed patients with invasive mycoses. The scientific data presented and the clinical experience and insight of the expert authors on the use of newer antifungal drugs in the pediatric population in the last section will beparticularly useful in guiding practicing pediatricians in the care of their patients. Perhaps the last chapter is one of the most valuable of all, putting in perspective the mycobiome, which, as a part of the microbiome, plays a key role in health and disease." Robert Gene Penn, MD (Nebraska Methodist Hospital) About the Author Mahmoud A. Ghannoum, PhD, MBA, FIDSA, FAAM joined Case Western Reserve University and University Hospitals Case Medical Center in 1996 from prior positions at the UCLA School of Medicine and Kuwait University. Dr. Ghannoum has spent his entire academic career studying medically important fungi encompassing different fungal pathogens including Candida, Aspergillus, and Cryptococcus, the major causes of fungal infections. He has published more than 350 peer-reviewed articles addressing various aspects of superficial and systemic fungal infections. More recently, he published the first study describing the oral mycobiome of healthy individuals. He has published extensively in the area of fungal pathogenesis with special focus on virulence factors including phospholipase B, germination, adhesion, and biofilm formation, both in vitro and in vivo. Dr. Ghannoum is a professor and director of the Center for Medical Mycology at Case Western Reserve University and University Hospitals Case Medical Center. This center of excellence, which he directs, is a multidisciplinary center that combines basic and translational research investigating fungi from the test tube to the bedside. He has performed several studies investigating the mechanisms underlying Candida pathogenesis. He is the recipient of the Freedom to Discover Award from Bristol- Myers Squibb and the Rhoda Benham Award from the Medical Mycological Society of the Americas. He served as a chairman of the Subcommittee on Antifungal Susceptibility Testing, Clinical Laboratory Standards Institute, and was selected as a "Most Interesting Person" by Cleveland Magazine in 2013. Dr. Ghannoum is an entrepreneur-scientist who has launched a number of companies focusing on the treatment of biofilm infections and microbial dysbiosis as it relates to gut health. He coined the term ‘Mycobiome’. John R. Perfect, MD, is James B. Duke Professor of Medicine at Duke University Medical Center, a faculty member of the Duke Universi