Academic Press Scientific Principles of Adipose Stem Cells

Scientific Principles of Adipose Stem Cells provides readers with in-depth and expert knowledge on adipose stem cells, their developmental biologic origins, foundational research on ASC signaling mechanisms and immunomodulatory properties, and clinical insights into applications in regenerative medicine.  Topics covered include basic adipose stem cell developmental biology and mechanisms of regulating self-renewal and activation in the stem cell niche, important methods for isolation and characterizing ASCs, and data on the impact on human demographics (age, sex, BMI) on ASC phenotype. A section devoted to ASC biology, ASCs for stem cell therapy and regenerative medicine, and ASCs in tissue engineering applications are also included. The book is written for scientists and clinicians who are broadly familiar with stem cells and basic cell biology principles and those seeking advanced information on adipose stem cells. Review A resource for scientists and clinicians who are broadly familiar with stem cells and basic cell biology principles From the Back Cover Scientific Principles of Adipose Stem Cells provides readers with in depth and expert knowledge on adipose stem cells in regards to developmental biologic origins, foundational research on ASC signaling mechanisms and immunomodulatory properties and clinical insights into applications in regenerative medicine. Written for scientists and clinicians who are broadly familiar with stem cells and basic cell biology principles and are seeking advanced information on adipose stem cells. Topics covered include basic adipose stem cell developmental biology (maturation process during embryogenesis) and mechanisms of regulating self-renewal and activation in the stem cell niche, important methods for isolation and characterizing ASCs, as well as known data any impact of human demographics (age, sex, BMI) on ASC phenotype. A section devoted to ASC biology, additional sections are devoted to ASCs for stem cell therapy and regenerative medicine, as well as ASCs in tissue engineering applications. Given the broad applications for which ASCs are used, as well as the interest in basic ASC science, Scientific Principles of Adipose Stem Cells transcends an audience of plastic surgeons and provides valuable and expert knowledge in developmental and cell biology appealing to basic scientists in a variety of fields. Information on cell manufacturing and commercialization, FDA regulations and ASC exosomes which appeal to those working in industry and applications of ASCs in cutting edge tissue engineering applications such as microphysiologic systems and/or bioreactors, are also included. These new technologies have important applications in drug discovery and for studying genetically modified ASCs. About the Author Dr. Kokai is co-director of the Adipose Stem Cell Center at the University of Pittsburgh, faculty of the McGowan Institute of Regenerative Medicine (MIRM) and research faculty member in the Department of Plastic Surgery, School of Medicine. Dr. Kokai has a broad background in soft tissue engineering with specific training in development of novel biomaterials and drug delivery systems for adipose tissue regeneration and use of mesenchymal stem cells for tissue engineering and cell therapy applications. She has extensive experience in developing bioassays for biologic product development and has led collaborations with industry partners to transition preclinical research into commercialized products. Dr. Kokai is a co-Investigator in an NIH funded line of research aimed at developing cell-based methods for clinical soft tissue reconstruction after cancer therapy. Dr. Marra is an Associate Professor in the Department of Plastic Surgery (Primary), and Department of Bioengineering (Secondary), at the University of Pittsburgh. Dr. Marra’s academic training was in the areas of polymer chemistry, biomaterials and tissue engineerin