Springer Cardiac Extracellular Matrix: Fundamental Science to Clinical Applications: 1098 (Advances in Experimental Medicine and Biology)

This book on cardiac extracellular matrix (ECM) features three sections, Fundamental Science, Pre-Clinical and Translational Science, and Clinical Applications. In the Fundamental Science section, we will cover the spectrum of basic ECM science from ECM’s role in development, biomechanical properties, cardiac ECM influence of cardiomyocyte biology, pathophysiology of ECM in heart disease, and ECM in tissue engineering. Section two, Preclinical and Translational Science, will discuss cardiac ECM technologies in the clinical pipeline including approaches to ECM as a therapeutic, animal models of cardiac research, tracking and imaging methods of cardiac ECM, and cGMP manufacturing and regulatory considerations for ECM based therapeutics. Finally, the third section, Clinical Applications, will highlight the clinical experience around cardiac ECM including therapeutic strategies targeting scar tissue in the heart, Clinical trial design and regulatory considerations, current human clinical trials in cardiovascular medicine and the role of pharmaceutical and biotech companies in the commercialization of ECM technologies for cardiovascular indications. This book provides a comprehensive review for basic and translational researchers as well as clinical practitioners and those involved in commercialization, regulatory and entrepreneurial activities. From the Back Cover This book on cardiac extracellular matrix (ECM) features three sections,  Fundamental Science, Pre-Clinical and Translational Science, and  Clinical Applications. In the Fundamental Science section, we will cover the spectrum of basic ECM science from ECM’s role in development, biomechanical properties, cardiac ECM influence of cardiomyocyte biology, pathophysiology of ECM in heart disease, and ECM in tissue engineering. Section two, Preclinical and Translational Science, will discuss cardiac ECM technologies in the clinical pipeline including approaches to ECM as a therapeutic, animal models of cardiac research, tracking and imaging methods of cardiac ECM, and cGMP manufacturing and regulatory considerations for ECM based therapeutics. Finally, the third section, Clinical Applications, will highlight the clinical experience around cardiac ECM including therapeutic strategies targeting scar tissue in the heart, Clinical trial design and regulatory considerations, current human clinical trials in cardiovascular medicine and the role of pharmaceutical and biotech companies in the commercialization of ECM technologies for cardiovascular indications. This book provides a comprehensive review for basic and translational researchers as well as clinical practitioners and those involved in commercialization, regulatory and entrepreneurial activities. About the Author Eric Schmuck, PhD, is a Senior Scientist with the Division of Cardiovascular Medicine at the University of Wisconsin-Madison School of Medicine and Public Health where he leads multi-disciplinary research teams focused on bringing regenerative medicine therapies to the clinic. He received his PhD in Human Physiology from the University of Wisconsin-Madison and is an expert in cardiac extracellular matrix and translational research models, specifically focusing on cardiac regeneration. His major research interests are in cardiac extracellular matrix, bioengineering and regenerative medicine therapies for the heart.  He has authored numerous peer-reviewed manuscripts and book chapters in the regenerative medicine field and holds multiple patents on cardiac extracellular matrix technologies. Finally, he is a co-founder and Chief Scientific Officer of Cellular Logistics Inc., a biotech company developing innovative biomaterial solutions to enhance stem cell retention for the treatment of advanced cardiovascular disease. Peiman Hematti, MD is Professor of Medicine in section of Hematology/Oncology, UW-Madison School of Medicine and Public Health, with joint appointm