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£97.37

Elsevier Validamycin and Its Derivatives: Discovery, Chemical Synthesis, and Biological Activity

Name: Validamycin and Its Derivatives: Discovery, Chemical Synthesis, and Biological Activity
Brand: Elsevier
Price: 97.37 GBP
Availability: InStock

Pharmacology

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Description

Validamycin and Its Derivatives: Discovery, Chemical Synthesis and Biological Activity presents, for the first time, a complete review of the underlying chemistry, synthesis, behavior and application of these compounds. Beginning with an introduction to validamycin, the book then outlines the key elements of its discovery and production, including details of its structures, isolation, analysis, and issues relating to its large scale production. Biological activities are then explored in more detail, followed by details of biosynthesis. Further to this, the chemical synthesis of validamycin and its intermediates, including valienamine, validamine, valiolamine, and validoxylamines is reviewed, before preparation of these derivatives and their biological activities are explored. Finally, the book concludes with a discussion of the economic aspects of working with validamycin and its potential in future applications and trends. With its detailed chemical coverage from a team of expert authors, this detailed guide can be applied to the large-scale industrial production of antibiotics and the adaptation of bioactive agents, from agricultural, to novel pharmaceutical applications. Offers complete coverage of validamycin chemistry from a highly experienced team of authors Encourages the discovery of further novel drugs based on validamycin derivatives Presents an interesting model for establishing new pharmaceutical leads from agricultural sources Includes coverage of the total chemical synthesis of validamycin and its intermediates, including valienamine, validamine, valiolamine and validoxylamines Review Reviews how medicinal chemists are employing the bioactive properties of validamycin and its related agricultural antibiotics in novel pharmaceutical drugs About the Author Professor Chen and his team have decades of experience working with Validamycin. Their research originally spanned its initial discovery, development and production as an agricultural antibiotic, and is now focussed on exploring its recent adaptation to a pharmaceutical lead with a multitude of potential applications. The group have published numerous papers on their work, including an important review on the preparation of Validamycin derivative Valienamine in 2003, followed by another key review on the preparation of Voglibose in 2006. In addition, they hold a number of patents relating to the degradation of Validamycin to produce Valienamine. Institute of Fermentation Engineering, Zhejiang University of Technology, PR China Institute of Fermentation Engineering, Zhejiang University of Technology, PR China Institute of Fermentation Engineering, Zhejiang University of Technology, PR China

Product Specifications

Brand: Elsevier
Format: paperback
ASIN: 0081009992
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Other Branches of Medicine > Pharmacology
Domain: Amazon UK
Release Date: 01 May 2017
Listed Since: 12 October 2016

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Elsevier Validamycin and Its Derivatives: Discovery, Chemical Synthesis, and Biological Activity

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