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Brand: Nova Science Pub Inc Tumor Suppressor Genes - Nova Science Medical Reference

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Description

Tumor suppressor genes play a critical role in preventing cellular transformation into cancer cells by reducing the probability of malignant development in multicellular organisms. This comprehensive reference explores how mutations or deletions in these genes increase the likelihood of tumour formation and examines the fundamental two-hit hypothesis that governs their function. Unlike oncogenes, most tumour suppressor genes require damage to both alleles before manifesting clinical effects, since a single functional allele can still produce the necessary protective protein. The text delves into the molecular mechanisms underlying tumour suppression, the exceptions to the two-hit model, and the implications for cancer development and prevention. Published by Nova Science Publishers Inc, this medical resource provides essential knowledge for healthcare practitioners, researchers, and students studying oncology, internal medicine, and cancer biology.

Key Features

The book examines tumour suppressor genes and their role in reducing the probability of cancer cell formation in multicellular organisms.

Comprehensive coverage of the two-hit hypothesis explains why both alleles must be affected in most tumour suppressor genes for tumour development to occur.

Detailed discussion of how mutations or deletions in tumour suppressor genes increase the likelihood of tumour formation compared to normal cellular function.

The text addresses exceptions to the two-hit model where mutations in single alleles can produce observable effects in tumour suppression.

Published by Nova Science Publishers Inc as a medical reference for oncology practitioners and healthcare professionals studying diseases and disorders.

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