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£108 today · previous high £108 · all-time low £108

Springer Targeted Drug Strategies for Cancer and Inflammation - Springer

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Description
This Springer publication explores folate pathways and their critical role in metabolism and macromolecule synthesis, examining antifolate drugs that leverage the reduced-folate carrier for therapeutic benefit. The book covers essential inhibitors including methotrexate targeting dihydrofolate reductase, alongside thymidylate synthase inhibitors such as raltitrexed and pemetrexed. Readers will discover major advances from the past decade, including the clinical approval of pemetrexed for treating lung cancer and mesothelioma, and insights into how cell membrane-anchored folate receptors can be exploited for improved drug delivery and efficacy. Designed for medical practitioners and researchers, this comprehensive resource bridges fundamental folate research with practical applications in oncology and inflammatory disease treatment.

Key Features

Covers antifolate drugs transported via the reduced-folate carrier and their mechanisms of action against folate-dependent enzymes.

Examines methotrexate as a dihydrofolate reductase inhibitor and explores its therapeutic applications in cancer and inflammatory conditions.

Discusses pemetrexed and raltitrexed as thymidylate synthase inhibitors approved for lung cancer and mesothelioma treatment.

Explores cell membrane-anchored folate receptors and their exploitation for targeted drug delivery strategies.

Provides insights into folate pathway metabolism and macromolecule synthesis relevant to cancer and inflammation therapies.

Product Specifications
Brand
Springer
Format
paperback
ASIN
1489988866
Category
Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Internal Medicine > Diseases & Disorders > Oncology
Domain
Amazon UK
Release Date
01 October 2014
Listed Since
01 October 2014

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