£114.71

Springer - Resistance to Proteasome Inhibitors in Cancer

Name: Springer - Resistance to Proteasome Inhibitors in Cancer
Brand: Springer
Price: 114.71 GBP
Availability: InStock

Oncology

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Description

This academic text from Springer examines the complex landscape of proteasome inhibitor resistance in human cancers. It provides a detailed look at why drugs like bortezomib and carfilzomib encounter challenges in treating conditions such as multiple myeloma. By investigating the molecular mechanisms behind these resistances, the book offers a deep understanding of how cancer cells adapt to targeted therapies. Readers will learn about cutting-edge strategies designed to overcome these barriers. The content covers the development of second generation 20S proteasome inhibitors and the potential of novel combinational therapies. It also explores new targets within the ubiquitin-proteasome pathway, including ubiquitin E3 ligases, deubiquitinases, and 19S proteasomal ATPases. Additional topics include the roles of histone deacetylases, oxidative stress, and proteotoxic stress pathways. The book also addresses pharmacogenomic signature profiling as a method for understanding resistant cancer cells. This resource is a valuable addition for medical professionals and researchers focused on advancing targeted anti-cancer therapeutics.

Key Features

Examines the mechanisms of action and resistance for proteasome inhibitors like bortezomib and carfilzomib in human cancers.

Explores second generation 20S proteasome inhibitors and novel combinational therapy strategies to combat drug resistance.

Identifies new targets in the ubiquitin-proteasome pathway, such as ubiquitin E3 ligases and deubiquitinases.

Covers the impact of 19S proteasomal ATPases, histone deacetylases, and oxidative stress on resistant cancer cells.

Discusses pharmacogenomic signature profiling and proteotoxic stress pathways in the context of targeted therapeutics.

Product Specifications

Brand: Springer
Format: paperback
ASIN: 3319377035
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Internal Medicine > Diseases & Disorders > Oncology
Domain: Amazon UK
Release Date: 22 September 2016
Listed Since: 08 July 2016

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Springer - Resistance to Proteasome Inhibitors in Cancer

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