Resistance to Proteasome Inhibitors in Cancer - Springer - Image 1

£114.71

Springer Resistance to Proteasome Inhibitors in Cancer - Springer

Name: Resistance to Proteasome Inhibitors in Cancer - Springer
Brand: Springer
Price: 114.71 GBP
Availability: InStock

Oncology

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Description

This comprehensive academic text examines advanced strategies for overcoming proteasome inhibitor resistance in cancer therapy. The book analyses mechanisms of action and resistance patterns associated with proteasome inhibitors such as bortezomib and carfilzomib across human cancers, including multiple myeloma and mantle cell lymphoma. Readers will discover cutting-edge approaches utilising second generation 20S proteasome inhibitors, novel combinational therapies, and emerging targets within the ubiquitin-proteasome pathway. The content addresses ubiquitin E3 ligases, deubiquitinases, 19S proteasomal ATPases, histone deacetylases, oxidative stress and proteotoxic stress pathways, alongside pharmacogenomic signature profiling in resistant cancer cells. Essential for oncologists, cancer researchers, and medical professionals seeking to understand and combat therapeutic resistance.

Key Features

Explores mechanisms of proteasome inhibitor resistance in bortezomib and carfilzomib treatment across multiple myeloma and mantle cell lymphoma.

Covers second generation 20S proteasome inhibitors and novel combinational therapy strategies for overcoming resistant cancer cells.

Examines ubiquitin-proteasome pathway targets including E3 ligases, deubiquitinases, and 19S proteasomal ATPases in cancer resistance.

Addresses histone deacetylases, oxidative stress, and proteotoxic stress pathways as resistance mechanisms and therapeutic opportunities.

Includes pharmacogenomic signature profiling approaches for personalised treatment strategies in proteasome inhibitor-resistant cancers.

Product Specifications

Brand: Springer
Format: paperback
ASIN: 3319377035
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Internal Medicine > Diseases & Disorders > Oncology
Domain: Amazon UK
Release Date: 22 September 2016
Listed Since: 08 July 2016

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Springer Resistance to Proteasome Inhibitors in Cancer - Springer

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