£112.67

About as cheap as it gets — within 5% of the all-time low it hit 2 months ago.

£113 today · all-time low £108 (Aug 2026) · usually £113

Springer Cullin-RING Ligases and Protein Neddylation: Biology and Therapeutics

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Description

This comprehensive guide explores Cullin-RING E3 Ubiquitin Ligases (CRLs) and their critical roles in cellular biology and disease. The book examines CRL structure, regulation through neddylation, and mechanistic details of protein ubiquitination processes that extend beyond standard cellular mechanisms. Discover how these ligases function in diverse biological processes and contribute to human diseases, particularly cancer development and progression. The content addresses genetic aspects, regulatory pathways, disease involvement, and emerging therapeutic applications. Ideal for researchers, healthcare practitioners, and scientists investigating targeted drug discovery and advanced treatment strategies involving ubiquitin ligase systems.

Key Features

Covers CRL structure, biology, and genetics with detailed mechanistic explanations of protein neddylation and ubiquitination.

Explores the regulatory role of neddylation in activating Cullin-RING E3 Ubiquitin Ligases across diverse biological pathways.

Addresses the involvement of CRLs in human disease, particularly cancer, and their potential targets for therapeutic intervention.

Provides insights into drug discovery strategies and targeted therapies utilising Cullin-RING Ligase mechanisms.

Part of the Advances in Experimental Medicine and Biology series (Volume 1217) from Springer, offering peer-reviewed research content.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
03 January 2021
Listed Since
07 December 2020

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