CRC Press Maspin (Medical Intelligence Unit, Unit 32) Book

Explore the foundational research on Maspin, a mammary serpin (or serine) protease inhibitor, in this comprehensive volume from CRC Press. As the first compilation of major research findings regarding this specific protein, this book provides deep insight into its discovery and biological significance. Originally identified through subtractive hybridization and differential display analyses, Maspin was found by comparing gene expression differences between normal mammary epithelium and invasive carcinoma cells. This research stems from the laboratory of Dr. Ruth Sager, a world-renowned geneticist at the Dana Farber Cancer Institute and Harvard Medical School. This text serves as a vital resource for those studying oncology and gene expression, following the initial scientific introduction of Maspin to the research community via Science (v263:526-52). It offers a detailed look at the molecular developments that have shaped our understanding of mammary protease inhibitors.