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Elsevier Regulators and Effectors of Small GTPases: Rho Family - Volume 406

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Description

This comprehensive Methods in Enzymology volume explores the regulatory mechanisms and effector interactions of small GTPases within the Rho family. As part of the broader Ras superfamily encompassing over 150 human members, Rho GTPases play essential roles in cytoskeletal regulation and cellular signalling. The volume examines how these molecular switches are controlled through guanine nucleotide exchange factors (GEFs) that promote GTP loading and GTPase activating proteins (GAPs) that enhance GTP hydrolysis. This detailed scientific resource provides researchers with current methodologies and insights into how small GTPases interact with their regulatory molecules and downstream effectors, making it invaluable for biochemists and molecular biologists studying signal transduction, cell structure dynamics and protein interaction networks.

Key Features

Small GTPases within the Rho family are comprehensively covered, including their roles in cytoskeletal organisation and cell signalling.

Detailed examination of guanine nucleotide exchange factors (GEFs) and their mechanisms for controlling GTP loading on Rho GTPases.

GTPase activating proteins (GAPs) are explored for their function in regulating GTP hydrolysis and inactivating small GTPases.

Methods in Enzymology Volume 406 provides practical experimental approaches and protocols for studying Rho family regulators.

Coverage includes interactions between small GTPases and their downstream effector proteins in cellular signalling pathways.

Product Specifications

Format
hardcover
Domain
Amazon UK
Release Date
25 February 2006
Listed Since
22 December 2006

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