Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases - Image 1

£130.77

Springer Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases

Name: Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases
Brand: Springer
Price: 130.77 GBP
Availability: InStock

General Medical Issues

It has never been this cheap. We have no record of a lower price.

£131 today · cheaper than every other day in the last 24 months

NEW HERE?

Amazon shows you one price. We show you all of them.

Tosheroon watches Amazon prices so you don't have to. Every product on Amazon has a price history — we make it visible. Set the price you'd actually pay, and we'll email you the second it gets there. No app, no account, one email.

WHAT'S ON THIS PAGE

↓ Price chart
when this has been cheap or pricey

↓ Forecast
where the price is heading next

↓ Statistics
all-time high & low, recent range

↑ Price alert
name your number, we'll email you

Price History & Forecast

Grey patches = out of stock. Cheaper = lower on the chart. Hover for exact prices.

Last 584 days • 584 data points (No recent data available)

Historical

Generating forecast...

Price Distribution

Price distribution over 584 days • 6 price levels

Days at Price

Current Price

Price Analysis

Most common price: £147 (211 days, 36.1%)

Price range: £131 - £147

Price levels: 6 different prices over 584 days

Description

Amyloid-forming proteins are implicated in over 30 human diseases. The proteins involved in each disease have unrelated sequences and dissimilar native structures, but they all undergo conformational alterations to form fibrillar polymers. The fibrillar assemblies accumulate progressively into disease-specific lesions in vivo. Substantial evidence suggests these lesions are the end state of aberrant protein folding whereas the actual disease-causing culprits likely are soluble, non-fibrillar assemblies preceding the aggregates. The non-fibrillar protein assemblies range from small, low-order oligomers to spherical, annular, and protofibrillar species. Oligomeric species are believed to mediate various pathogenic mechanisms that lead to cellular dysfunction, cytotoxicity, and cell loss, eventuating in disease-specific degeneration and systemic morbidity. The particular pathologies thus are determined by the afflicted cell types, organs, systems, and the proteins involved. Evidence suggests that the oligomeric species may share structural features and possibly common mechanisms of action. In many cases, the structure–function interrelationships amongst the various protein assemblies described in vitro are still elusive. Deciphering these intricate structure–function correlations will help understanding a complex array of pathogenic mechanisms, some of which may be common across different diseases albeit affecting different cell types and systems.

Product Specifications

Brand: Springer
Format: Hardcover
ASIN: 9400727739
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > General Medical Issues
Domain: Amazon UK
Release Date: 13 January 2012
Listed Since: 26 September 2011

Barcode

No barcode data available

Springer Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases

It has never been this cheap. We have no record of a lower price.

Price History & Forecast

Price Distribution

Price Analysis

Description

Product Specifications

Barcode

Similar Products You Might Like

The Nature and Origin of Amyloid Fibrils: v. 199 (Novartis Foundation Symposia)

Bacterial Amyloids: Methods and Protocols: 2538 (Methods in Molecular Biology, 2538)

The Three Functional States of Proteins: Structured, Intrinsically Disordered, and Phase Separated

The Functional Fold: Amyloid Structures in Nature

Biological Soft Matter: Fundamentals, Properties, and Applications

Amyloidosis and Fabry Disease: A Clinical Guide

Cellular Osmolytes: From Chaperoning Protein Folding to Clinical Perspectives

Biophysics And Biochemistry Of Protein Aggregation: Experimental And Theoretical Studies On Folding, Misfolding, And Self-Assembly Of Amyloidogenic ... Lecture And Course Notes In Chemistry)

Helical Wormlike Chains in Polymer Solutions

Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease: 65 (Subcellular Biochemistry, 65)

Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease: 65 (Subcellular Biochemistry, 65)

Protein Scaffolds: Design, Synthesis, and Applications: 1798 (Methods in Molecular Biology, 1798)

The Physics of Protein Structure and Dynamics: When and Why Proteins Fold or Don’t Fold

Protein Misfolding, Aggregation and Conformational Diseases: Part A: Protein Aggregation and Conformational Diseases: 4 (Protein Reviews, 4)

Amyloid and Amyloidosis 1990: VIth International Symposium on Amyloidosis August 5-8, 1990, Oslo, Norway (Amyloid and Amyloidosis: International Symposium Proceedings)

Amyloid Proteins: Methods and Protocols: 1779 (Methods in Molecular Biology, 1779)

Adsorption, Aggregation and Structure Formation in Systems of Charged Particles: From Colloidal to Supracolloidal Assembly (Springer Theses)

Oligomerization in Health and Disease (Volume 117) (Progress in Molecular Biology and Translational Science, Volume 117)

Protein Self-Assembly: Methods and Protocols: 2039 (Methods in Molecular Biology, 2039)

Fibrous Proteins: Amyloids, Prions and Beta Proteins (Volume 73) (Advances in Protein Chemistry, Volume 73)

Membrane Protein Structure and Function Characterization: Methods and Protocols: 1635 (Methods in Molecular Biology, 1635)

Protein Physics: A Course of Lectures (Soft Condensed Matter, Complex Fluids and Biomaterials)

Structure, Cellular Synthesis and Assembly of Biopolymers: 19 (Results and Problems in Cell Differentiation, 19)

Springer - Physical Biology of Proteins and Peptides Book