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Новые α-глюкозидазы как ингибиторы противодиабетических препаратов: In silico Approaches

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Description

В этой книге различные методы компьютерного проектирования лекарств (CADD) были использованы для разработки новых ингибиторов, которые могут быть использованы для лечения диабета. Трехмерная количественная связь структура-активность (3D-QSAR) и молекулярный докинг были применены для открытия и рационализации новых биологически активных азотсодержащих гетероциклических молекул в качестве новых ингибиторов α-глюкозидазы. Кроме того, для оценки пероральной биодоступности и изучения токсичности новых разработанных молекул использовались правило пяти Липински и фармакокинетика ADME/Tox. Все методы in silico показали многообещающие результаты в качестве антидиабетических препаратов-кандидатов. Поэтому результаты, полученные в этой книге, стимулируют дальнейшие экспериментальные и научные исследования новых разработанных соединений, которые могут стать противодиабетическими средствами с высокой ингибирующей способностью. В этой книге мы сосредоточимся на обсуждении многих интересных научных статей, опубликованных нашей исследовательской группой в ряде известных национальных и международных журналов.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
03 December 2023
Listed Since
04 December 2023

Barcode

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