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Neue α-Glucosidase als antidiabetische Inhibitoren: In silico-Ansätze

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Description

In diesem Buch wurden verschiedene CADD-Methoden (Computer Aided Drug Design) verwendet, um neue Inhibitoren zu entwerfen, die zur Behandlung von Diabeteserkrankungen eingesetzt werden können. 3-dimensionale quantitative Struktur-Aktivitäts-Beziehungen (3D-QSAR) und molekulare Docking-Ansätze wurden angewandt, um neue bioaktive stickstoffhaltige heterozyklische Moleküle als neue α-Glucosidase-Inhibitoren zu entdecken und zu rationalisieren. Darüber hinaus wurden Lipinskis Fünferregel und ADME/Tox-Pharmakokinetik verwendet, um die orale Bioverfügbarkeit zu bewerten und die Toxizität der neu entwickelten Moleküle zu untersuchen. Alle In-silico-Methoden zeigen vielversprechende Ergebnisse als antidiabetische Wirkstoffkandidaten. Außerdem besteht keine chemische Ähnlichkeit zwischen den entwickelten Verbindungen und den in der Literatur oder in Datenbanken untersuchten Arzneimitteln. Daher ermutigen die in diesem Buch erzielten Ergebnisse zu weiteren experimentellen und wissenschaftlichen Untersuchungen neu entwickelter Verbindungen, die als antidiabetische Wirkstoffe mit hoher Hemmwirkung in Frage kommen. Wir werden uns in diesem Buch auf die vielen interessanten wissenschaftlichen Artikel konzentrieren, die von unserer Forschungsgruppe in einer Reihe von renommierten nationalen und internationalen Zeitschriften veröffentlicht wurden.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
03 December 2023
Listed Since
04 December 2023

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