£71.00

Neue Antimalariakombinationen für chloroquinresistente Malaria: Chloroquinresistentes Plasmodium falciparum in Indien und Entwicklung neuer Malariakombinationen

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Description

Malaria betrifft 300-500 Millionen Menschen auf der Welt und die Sterblichkeit liegt zwischen 1-2 Millionen, wobei Kinder in Afrika am anfälligsten sind. Da kein Impfstoff gegen Malaria verfügbar ist und Medikamente an vorderster Front wie Chloroquin und Antifolate eine weit verbreitete Parasitenresistenz registrieren, ist die Herausforderung der Malariabehandlung eine gewaltige Aufgabe. Während die Forschung zur Entdeckung neuer Medikamente unerlässlich geworden ist, ist es auch notwendig geworden, kurzfristig therapeutische Strategien zu identifizieren. Ein Ansatz besteht darin, zu prüfen, ob bekannte Medikamente, die für andere Anwendungen verwendet werden, zur Behandlung von Malaria eingesetzt werden können. Eine zweite Strategie besteht darin, nach natürlichen Verbindungen mit Antimalariaaktivität zu suchen, entweder einzeln oder in Kombination. Die Kombinationstherapie hat im Zusammenhang mit Artemisinin-Derivaten, die die einzigen getesteten, wirksamen Antimalariamittel sind, die im Korb verbleiben, eine beträchtliche Bedeutung erlangt. Eine Kombinationstherapie mit einem Artemisinin-Derivat kann ein Wiederauftreten aufgrund einer Monotherapie verhindern, die Lebensdauer des Medikaments verlängern und möglicherweise auch die Therapiekosten senken.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
07 March 2023
Listed Since
08 March 2023

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