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Développement de liposomes pour le traitement des verrues cutanées

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Description

L'objectif de ce travail de recherche était de concevoir de nouveaux liposomes contenant des médicaments hydrophiles et hydrophobes en utilisant la méthode d'éjection de l'éthanol modifiée pour formuler les liposomes et les optimiser sur la base d'un plan factoriel complet de 32. L'effet des variables indépendantes a été déterminé sur les variables dépendantes. La formulation de liposomes F9 a montré un piégeage plus élevé du médicament et une libération contrôlée du médicament. De petites vésicules multilamellaires, avec des tailles allant d'environ 117 à 200 nm, ont été obtenues avec succès. Les résultats ont indiqué une influence significative des quantités de phospholipides sur la taille des liposomes et l'efficacité de l'encapsulation. En raison de la variabilité de leur composition et de leurs propriétés structurelles, les liposomes sont extrêmement polyvalents, ce qui conduit à un grand nombre d'applications, notamment dans les domaines industriels pharmaceutiques, cosmétiques et alimentaires. Une étude a montré que les liposomes ne sont pas stables à haute température, mais que les formulations sont plus stables lorsqu'elles sont stockées à basse température, c'est-à-dire à 4oC. Ainsi, dans les liposomes, nous avons réussi à incorporer des médicaments hydrophiles et hydrophobes et ils peuvent être utilisés pour le développement de formulations.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
18 August 2022
Listed Since
19 August 2022

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