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Síntesis y estudios bioactivos de algunos nuevos flavonoides C-metilados

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Description

Estos compuestos poseen una serie de actividades biológicas y se emplean en el tratamiento de enfermedades comunes. El estudio de la literatura reveló que las chalconas, flavanonas y auronas poseen un amplio espectro de actividades biológicas como antimicrobianas, antiinflamatorias, antipalúdicas, antidepresivas, antihistamínicas, antituberculosas y anticancerígenas. Esta tesis es un esfuerzo en esta dirección de síntesis y caracterización de tales compuestos basados en 1H NMR, 13CNMR, espectroscopia de masas y análisis elemental. Se ha sintetizado por primera vez una de las flavanonas recientemente aisladas (pisonivanona) de la Pisonia aculeate L. En el presente trabajo se sintetizaron por primera vez un total de 30 compuestos, incluyendo una serie de 16 chalconas (3a-p) excepto la 3e, 9 flavanonas (4a-h&5) y 5 auronas (5a-e). Se desarrollaron dos nuevos métodos para la desmetilación de dichos flavonoides. El compuesto 3e y la acetofenona-1 se sintetizaron mediante métodos alternativos y eficaces a los anteriores.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
28 July 2022
Listed Since
29 July 2022

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