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Arqueas endosimbióticas y síndrome hiperamonémico

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Description

La endosimbiosis arcaica conduce a la inducción del fenotipo Warburg y al aumento de la glucólisis, así como a la disfunción mitocondrial. El piruvato generado como consecuencia de la cascada glucolítica entra en la derivación del GABA, donde se convierte en glutamato, GABA y succinil CoA. El piruvato se convierte en glutamato, sobre el que actúa la glutamato deshidrogenasa generando amoníaco. Las arqueas endosimbióticas pueden oxidar el amoníaco para su aprovechamiento energético. El catabolismo del colesterol de las arqueas, mediado por la colesterol oxidasa de las arqueas, también puede producir la oxidación del anillo de colesterol para generar piruvato. El piruvato es convertido en glutamato por la enzima glutamato-piruvato transaminasa sérica. El glutamato es transformado por la glutamato deshidrogenasa para generar amoníaco. La ureasa de las arqueas puede actuar sobre la urea generando amoníaco y tiocianato. Las arqueas son oxidantes del amoníaco y pueden utilizarlo como fuente de energía. La actividad de la ureasa arquea relacionada con la síntesis de amoníaco y tiocianato, así como la actividad de la colesterol oxidasa que genera piruvato y amoníaco, son importantes en la esquizofrenia, la malignidad, el síndrome metabólico X, las enfermedades autoinmunes y la degeneración neuronal.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
15 February 2022
Listed Since
16 February 2022

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