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LAP Lambert Academic Publishing Synthesis of Novel Heterocycles and Their Pharamacological Activity: Novel Heterocycles and its Pharmacological activity

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Description

Antibiotics are one of our most important weapons to cover bacterial infections and improve human life . Infectious diseases are the leaders among the challenging drug targets because of the multi-drug resist antimicrobial pathogens and continuous rise in the emerging infections from known and unknown sources. Tyrosine kinases are orally active, small molecules that have a favorable safety profile and can be easily combined with other forms of chemotherapy or radiation therapy. The combination of two pharmacophores into a single molecule is an effective and commonly used direction in modern medicinal chemistry for the exploration of novel and highly active compounds. A variety of safe and effective antiinflammatory agents are available, including aspirin and other nonsteroidal anti-inflammatories, with many more drugs under development. The pharmacophoric structural features of the selective COX-2 inhibitors possess a central heterocyclic five member ring system bearing two vicinal aryl moieties, such as pyrazole (celecoxib), 2(5H) furanone (rofecoxib), and isoxazole (valdecoxib).

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
25 August 2018
Listed Since
19 September 2018

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