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LAP Lambert Academic Publishing Synthesis of Heterocyclic Compounds with expected Bioligical Activity

Name: Synthesis of Heterocyclic Compounds with expected Bioligical Activity
Brand: LAP Lambert Academic Publishing
Price: 66.0 GBP
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Pharmacology

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Description

This work has been carried out to investigate the chemical reactivity and synthetic potentiality of 2-thioxohydropyridine 11a-d via their reaction with several active halogencontaining compounds to afford the corresponding 2-alkylthiopyridine in some cases and thieno[2,3-b]pyridine directly in most cases. Thieno[2,3-b]pyridine-2-carbohydrazides obtained through the reaction of 2-ethoxycarbonylthienopyridines with hydrazine hydrate which in turn, used to obtain the corresponding pyrimidinones 20-26(a-d), 1,3,4- oxdiazoles 28, 30(a-d), pyrazolothienopyridine derivatives (32a-d) thienopyridine-3- amines (34a-d), pyrazolones (36a-d), pyrazolidine-3,5-diones (38a-d). 3- Aminopyrazolopyridine obtained via the reaction of 11a-e or 49a-e with hydrazine hydrate which in turn, reacted with nitrous acid to give the diazonium salts 51a-e which coupled with several active-hydrogen containing reagents to give the corresponding triazines. The structures of all newly synthesized heterocyclic compounds were elucidated by considering the data of IR, 1H NMR (δppm), mass spectra as well as that of elemental analyses. Anti-Alzheimer, anti COX-2 and anti-Cancer activities were investigated for all newly

Product Specifications

Brand: LAP Lambert Academic Publishing
Format: paperback
ASIN: 3847311883
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Other Branches of Medicine > Pharmacology
Domain: Amazon UK
Release Date: 27 December 2011
Listed Since: 29 December 2011

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LAP Lambert Academic Publishing Synthesis of Heterocyclic Compounds with expected Bioligical Activity

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