The Contribution of Pigmentation towards UVB Radiation Protection: In A Mouse Model of Human Melanoma - Image 1

£43.00

LAP Lambert Academic Publishing The Contribution of Pigmentation towards UVB Radiation Protection: In A Mouse Model of Human Melanoma

Name: The Contribution of Pigmentation towards UVB Radiation Protection: In A Mouse Model of Human Melanoma
Brand: LAP Lambert Academic Publishing
Price: 43.0 GBP
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Biological Science

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Description

Ultraviolet B (UVB) radiation is the component of sunlight that damages DNA. Red-haired people are especially vulnerable to the damaging effects of UVB due to the low content of eumelanin in their skin. Accumulated damage from UVB can lead to skin cancer. A transgenic strain of mouse containing an inducible melanogenesis system was used to investigate the mechanism of protection of eumelanin. Melanogenesis in this murine model can be induced by the application of the diterpene, forskolin to the epidermis. Forskolin increases eumelanin protection by inducing the expression of cAMP, which then upregulates the expression of melanogenic genes. To assess the protection afforded by eumelanin to the epidermis, transgenic mice were exposed to varying doses of UVB in the presence or absence of forskolin induced melanin. DNA damage was assessed by immunohistochemical staining for cyclobutane pyrimidine dimers. Vehicle treated mice and albino mice showed thymine dimer formation at 20 and 50 mJ/cm^2 of UVB. Forskolin treated and black-skinned mice showed no thymine dimer formation at these doses. These results indicate direct UVB protection by eumelanin through a light filtering process.

Product Specifications

Brand: LAP Lambert Academic Publishing
Format: paperback
ASIN: 3845417005
Category: Books > Subjects > Science, Nature & Maths > Biological Sciences > Biological Science
Domain: Amazon UK
Release Date: 21 July 2011
Listed Since: 26 July 2011

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LAP Lambert Academic Publishing The Contribution of Pigmentation towards UVB Radiation Protection: In A Mouse Model of Human Melanoma

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