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EAE Editorial Academia Espanola Mecanismos Moleculares de la Respuesta Insulínica en Ratas Subnutridas: Estudio de los mecanismos moleculares que alteran la respuesta insulínica en ratas subnutridas

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Description

La subnutrición crónica establecida desde una etapa perinatal conduce a un incremento de la capacidad de respuesta a la insulina en los músculos esquelético y cardíaco de la rata adulta, con relación al transporte de la glucosa. Así los animales subnutridos son normotolerantes a la glucosa, a pesar de que su secreción insulínica se encuentra fuertemente disminuida. La subnutrición aumenta el estímulo de la insulina sobre la translocación de los transportadores de glucosa en el músculo de la rata adulta. Las ratas lactantes que se han subnutrido desde el último tercio de la gestación son normotolerantes a la glucosa a pesar de su escasa respuesta insulino-secretora. Ello se debe, al menos en parte, a un incremento de su capacidad de respuesta a la insulina sobre la translocación del GLUT-4, lo cual está ligado a un aumento del número de receptores de la hormona así como de varias etapas de su vía de señales posteriores al receptor. La subnutrición establecida, conduce a un aumento de GLUT-2 y GLUT-1 en el hígado de la rata lactante, así como de otras señales de la vía insulínica. Es posible que ello derive en una hipersensibilidad en algunas de las respuestas hepáticas hormonales.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
26 May 2011
Listed Since
02 June 2011

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No barcode data available

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