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ÉDITIONS UNIVERSITAIRES EUROPÉENNES Stress Oxydant et Homéostasie Glucidique au cours du Diabète de type 2

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Description

Le but de ce travail a été d’étudier l'adaptation β-cellulaire au stress oxydant dans un modèle animal de diabète de type 2, le rat GK/Par. Nous avons montré que les îlots de rats diabétiques sont protégés contre le stress oxydant en regard de la secretion d’insuline et de l’apoptose. Ces adaptations sont associées à une augmentation des gènes de défense contre les radicaux libres et l'apoptose. Nous avons aussi étudié le rôle d’une dysfonction endothéliale et du processus inflammatoire associés (phénomènes au potentiel fortement pro-oxydant) dans l’adaptation antioxydante. Les îlots diabétiques présentent une activation endothéliale, comme en témoigne la surexpression des gènes de la fibrolyse, de l’adhésion vasculaire, de l’inflammation et de l’angiogenèse. Le blocage de la voie IL-1 via un traitement in vivo par IL-1Ra chez le rat diabétique a permis de diminuer l’infiltration des cellules immunitaires, d’améliorer la vascularisation, de réduire la fibrose et de normaliser l’expression des défenses antioxydantes. Nous proposons que la surexpression d’antioxydants dans la cellule β diabétique soit responsable de sa dysfonction, prix à payer pour la protéger de la mort cellulaire.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
12 December 2018
Listed Since
08 January 2019

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