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Südwestdeutscher Verlag für Hochschulschriften Hypoxie und Strahlentherapie: Einfluss synthetischer und natürlicher HIF-Modulatoren auf Wachstum & Strahlensensibilität von humanen Tumorzellen

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Description

Infolge von Hypoxie werden ‚Hypoxie induzierbare Faktoren’ (HIF) in Tumorzellen stabilisiert. Die Aktivierung von HIF-1 korreliert negativ mit dem Erfolg einer Strahlentherapie und dem Überleben des Patienten. Ziel dieser Dissertation war es zu zeigen, dass eine Hemmung der Transkriptionsfaktoren HIF-1 und HIF-2 in vitro durch ausgewählte synthetische sowie natürliche Komponenten eine Strahlensensibilisierung sowie ein vermindertes Wachstum von Tumorzellen bewirken kann. Die in vitro Resultate der Experimente mit HIF-induzierten Tumorzellen bestätigen die HIF vermittelte Induktion von Strahlenresistenz in Tumorzellen. Dabei spielt es keine Rolle, ob HIF zuvor durch sauerstoffabhängige Mechanismen oder durch andere Faktoren wie ebenfalls untersuchte PHD-Inhibitoren stabilisiert wird. Diese Arbeit liefert weiterhin Belege, dass sich eine Ko-Therapie mit natürlichen Pflanzeninhaltsstoffen wie Kurkumin innerhalb der Krebsbehandlung positiv auswirken kann, da die Behandlung mit dieser Substanz zu einer Verminderung des Wachstums und des klonogenen Überlebens von Leber- und Brusttumorzellen führt, vermittelt über die Inhibierung von HIF und weiterer zellulärer Signalkaskaden.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
17 April 2012
Listed Since
25 March 2012

Barcode

No barcode data available

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