£67.00

Südwestdeutscher Verlag für Hochschulschriften Heterochromatin Protein 1? (HP1?): It's role on genomic stability and cellular senescence

Price data last checked 20 day(s) ago - will refresh soon

View at Amazon

We'll watch every seller, every day. One email when your price arrives.

It has never been this cheap. We have no record of a lower price.

£67 today · cheaper than every other day in the last 3 months

NEW HERE?

Amazon shows you one price. We show you all of them.

Tosheroon watches Amazon prices so you don't have to. Every product on Amazon has a price history — we make it visible. Set the price you'd actually pay, and we'll email you the second it gets there. No app, no account, one email.

WHAT'S ON THIS PAGE

↓ Price chart
when this has been cheap or pricey
↓ Forecast
where the price is heading next
↓ Statistics
all-time high & low, recent range
↑ Price alert
name your number, we'll email you

Price History & Forecast

Grey patches = out of stock. Cheaper = lower on the chart. Hover for exact prices.

Last 71 days · 71 data points (no recent data)

Historical
Generating forecast…
£67.00 £63.65 £64.99 £66.33 £67.67 £69.01 £70.35 09 July 2026 26 July 2026 13 August 2026 30 August 2026 17 September 2026

Price Distribution

Price distribution over 71 days • 1 price levels

Days at Price
71 days 0 18 36 53 71 £67 Days at Price

Price Analysis

Most common price: £67 (71 days, 100.0%)

Price range: £67 - £67

Price levels: 1 different prices over 71 days

Description

Heterochromatin protein 1 (HP1) proteins are fundamental units of heterochromatin packaging.In mammals,there are three HP1 homologues termed HP1?(Cbx5),HP1?(Cbx1) and HP1?(Cbx3).HP1? is the best characterized isoform.Murine HP1? is essential for organismal survival.This study demonstrates that Cbx1+/- and Cbx1-/- MEFs escape senescence crisis that is associated with chromosomal aberrations.Telomeres of late passage Cbx1-/- MEFs are longer than WT controls. Introduction of Cbx1-/- mutation in cells expressing H-rasV12 oncogene did not result senescence bypass.K-rasV12 oncogene expression in Cbx1+/- mice resulted in increased malignant adenocarcinomas.These data indicate that HP1? acts as a tumour suppressor.Other experiments showed that binding of HP1? to histone H3(HH3) is resistant to high salt concentrations.ITC experiments confirmed that binding affinity of HP1? for HH3 was 4 times higher than for H3K9me3.The high affinity binding of HP1? to the HH3 is shown to be stronger than the affinity to H3K9me3.Loss of this interaction might result in the perinatal lethal phenotype seen in Cbx1-/- mice.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
24 January 2011
Listed Since
09 January 2011

Barcode

No barcode data available

Similar Products You Might Like

Human Chromosomes & Aging
75% match

Human Chromosomes & Aging

£19.48 09 Sep 2026
Cellular Senescence and Tumor Suppression
75% match

Cellular Senescence and Tumor Suppression

Springer

£108.01 05 Aug 2026
Histone Mutations and Cancer: 1283 (Advances in Experimental Medicine and Biology, 1283)
75% match

Histone Mutations and Cancer: 1283 (Advances in Experimental Medicine and Biology, 1283)

Springer

£76.42 15 Sep 2026
Chromatin Dynamics in Cellular Function: 41 (Results and Problems in Cell Differentiation, 41)
74% match

Chromatin Dynamics in Cellular Function: 41 (Results and Problems in Cell Differentiation, 41)

Springer

£74.23 08 Aug 2026
Apoptosis, Senescence and Cancer (Cancer Drug Discovery and Development)
74% match

Apoptosis, Senescence and Cancer (Cancer Drug Discovery and Development)

Humana

£170.00 23 Aug 2026
Cellular Senescence and Tumor Suppression
73% match

Cellular Senescence and Tumor Suppression

Springer

£108.01 07 Aug 2026
Telomerases: Chemistry, Biology, and Clinical Applications
73% match

Telomerases: Chemistry, Biology, and Clinical Applications

Wiley

£99.31 06 Aug 2026
The Hippo Signaling Pathway and Cancer
73% match

The Hippo Signaling Pathway and Cancer

Springer

£108.01 08 Aug 2026
A NEW JOURNEY OF HU PROTEIN FAMILY: HU PROTEINS AS A NOVEL FAMILY OF NEURON- SPECIFIC REGULATORS FOR POST- TRANSCRIPTIONAL RNA PROCESSING
73% match

A NEW JOURNEY OF HU PROTEIN FAMILY: HU PROTEINS AS A NOVEL FAMILY OF NEURON- SPECIFIC REGULATORS FOR POST- TRANSCRIPTIONAL RNA PROCESSING

VDM Verlag

£59.00 17 Sep 2026
Tumor Dormancy, Quiescence, and Senescence, Volume 1: Aging, Cancer, and Noncancer Pathologies (Tumor Dormancy and Cellular Quiescence and Senescence, 1)
73% match

Tumor Dormancy, Quiescence, and Senescence, Volume 1: Aging, Cancer, and Noncancer Pathologies (Tumor Dormancy and Cellular Quiescence and Senescence, 1)

Springer

£150.58 05 Aug 2026
Some Aspects of Chromosome Structure and Functions
73% match

Some Aspects of Chromosome Structure and Functions

Narosa Publishing House

£95.00 13 Sep 2026
Geriatric Medicine: An Evidence-Based Approach (Geriatric Medicine (Cassel))
73% match

Geriatric Medicine: An Evidence-Based Approach (Geriatric Medicine (Cassel))

Springer

£96.30 18 Aug 2026
The p53 Family: A Subject Collection from Cold Spring Harbor Perspectives in Biology
72% match

The p53 Family: A Subject Collection from Cold Spring Harbor Perspectives in Biology

Cold Spring Harbor Laboratory Press

£85.00 08 Aug 2026
Gadd45 Stress Sensor Genes: 793 (Advances in Experimental Medicine and Biology)
72% match

Gadd45 Stress Sensor Genes: 793 (Advances in Experimental Medicine and Biology)

Springer

£89.99 08 Aug 2026
Cellular Senescence and Cardiac Aging: Mechanisms, Therapeutic Strategies, and Implications for Cardiovascular Diseases
72% match

Cellular Senescence and Cardiac Aging: Mechanisms, Therapeutic Strategies, and Implications for Cardiovascular Diseases

Elsevier

£145.99 04 Aug 2026
Tumor Dormancy, Quiescence, and Senescence, Volume 2: Aging, Cancer, and Noncancer Pathologies (Tumor Dormancy and Cellular Quiescence and Senescence, 2)
72% match

Tumor Dormancy, Quiescence, and Senescence, Volume 2: Aging, Cancer, and Noncancer Pathologies (Tumor Dormancy and Cellular Quiescence and Senescence, 2)

Springer

£108.01 08 Aug 2026
Patho-Epigenetics of Disease
72% match

Patho-Epigenetics of Disease

Springer

£92.69 07 Aug 2026
Telomere Territory and Cancer
72% match

Telomere Territory and Cancer

Springer

£107.98 06 Aug 2026
DNA REPAIR, GENETIC INSTABILITY, AND CANCER
72% match

DNA REPAIR, GENETIC INSTABILITY, AND CANCER

World Scientific Publishing Company

£92.00 23 Aug 2026
Cellular Senescence: Methods and Protocols: 1896 (Methods in Molecular Biology, 1896)
72% match

Cellular Senescence: Methods and Protocols: 1896 (Methods in Molecular Biology, 1896)

Humana

£73.14 26 Aug 2026
The Centrosome: Cell and Molecular Mechanisms of Functions and Dysfunctions in Disease
72% match

The Centrosome: Cell and Molecular Mechanisms of Functions and Dysfunctions in Disease

Humana

£80.67 06 Aug 2026
Epigenetics of Aging
72% match

Epigenetics of Aging

Springer

£108.01 06 Aug 2026
Histone Variants: Methods and Protocols: 1832 (Methods in Molecular Biology, 1832)
72% match

Histone Variants: Methods and Protocols: 1832 (Methods in Molecular Biology, 1832)

Humana

£88.21 05 Aug 2026
Telomeres and Telomerase: Methods and Protocols: 1587 (Methods in Molecular Biology, 1587)
72% match

Telomeres and Telomerase: Methods and Protocols: 1587 (Methods in Molecular Biology, 1587)

Humana

£80.67 05 Aug 2026