£83.04

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Birkhauser Aromatase Inhibitors (Milestones in Drug Therapy)

Amazon

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Last 54 days · 54 data points (no recent data)

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£83.04 £81.13 £81.54 £81.96 £82.38 £82.80 £83.21 26 July 2026 08 August 2026 21 August 2026 03 September 2026 17 September 2026
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Price distribution over 54 days • 3 price levels

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14 days 32 days 8 days · current 0 8 16 24 32 £81 £82 £83 Days at Price

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Most common price: £82 (32 days, 59.3%)

Price range: £81 - £83

Price levels: 3 different prices over 54 days

Description

Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years, hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action. The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgens into oestrogens by creating an aromatic ring in the steroid molecule (hence the enzyme's trivial name, aromatase). Whereas, the first aromatase inhibitors to be used therapeutically could be shown to produce drug-induced inhibition of the enzyme and therapeutic benefits in patients with breast cancer, they were not particularly potent and lacked specificity. However, second-generation drugs were developed and most recently third-generation inhibitors have evolved which possess remarkable specificity and potency. Initial results from clinical trials suggest that these agents will become the cornerstones of future endocrine therapy.

Product Specifications

Format
hardcover
Domain
Amazon UK
Release Date
01 June 2005
Listed Since
18 December 2006

Barcode

No barcode data available

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