Aromatase Inhibitors (Milestones in Drug Therapy) - Image 1

£82.50

Birkhauser Aromatase Inhibitors (Milestones in Drug Therapy)

Name: Aromatase Inhibitors (Milestones in Drug Therapy)
Brand: Birkhauser
Price: 82.5 GBP
Availability: InStock

Breast Cancer

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Description

Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years, hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action. The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgens into oestrogens by creating an aromatic ring in the steroid molecule (hence the enzyme's trivial name, aromatase). Whereas, the first aromatase inhibitors to be used therapeutically could be shown to produce drug-induced inhibition of the enzyme and therapeutic benefits in patients with breast cancer, they were not particularly potent and lacked specificity. However, second-generation drugs were developed and most recently third-generation inhibitors have evolved which possess remarkable specificity and potency. Initial results from clinical trials suggest that these agents will become the cornerstones of future endocrine therapy.

Product Specifications

Brand: Birkhauser
Format: Hardcover
ASIN: 3764371994
Category: Books > Subjects > Health, Family & Lifestyle > Health Issues > Illnesses & Conditions > Breast Cancer
Domain: Amazon UK
Release Date: 01 June 2005
Listed Since: 18 December 2006

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Birkhauser Aromatase Inhibitors (Milestones in Drug Therapy)

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