Natural Agents Against Liver Death: Modulatory Effects of Natural Products Against Ethanol-Induced Hepatocyte Death - Image 1

£60.00

LAP Lambert Academic Publishing Natural Agents Against Liver Death: Modulatory Effects of Natural Products Against Ethanol-Induced Hepatocyte Death

Name: Natural Agents Against Liver Death: Modulatory Effects of Natural Products Against Ethanol-Induced Hepatocyte Death
Brand: LAP Lambert Academic Publishing
Price: 60.0 GBP
Availability: InStock

Pharmacology

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Description

Liver is crucial to health and life. Liver cell death is a cardinal feature of almost every prevalent liver disease. Ethanol-induced cell death by necrosis and/or apoptosis is a valid model to test for hepatoprotective agents. Potential approaches include amino acids and phytochemicals. The pharmacologic effects of glycine (Gly), cysteine, N-acetylcysteine, Astragalus spinosus and Astragalus boeticus (A. boeticus) were investigated on hepatocyte death. Agents with cytoprotective effects were further examined by estimating reduced glutathione, lipid peroxidation and membrane blebbing. Moreover, the molecular mechanisms underlying Gly hepatoprotection were studied using isolated rat hepatocytes. Caspase-3 activity, chromatin condensation and cytochrome c translocation were assessed. In conclusion, both Gly and A. boeticus demonstrated promising hepatoprotective effects. Particularly, Gly could be a very effective drug to ameliorate liver injuries because it prevents both forms of hepatocyte death. This study should be especially useful to pharmacologists, clinical hepatologists, nutritionists, and to every liver patient who might benefit one day from this experimental research.

Product Specifications

Brand: LAP Lambert Academic Publishing
Format: paperback
ASIN: 3659901539
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Other Branches of Medicine > Pharmacology
Domain: Amazon UK
Release Date: 22 August 2016
Listed Since: 31 August 2016

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LAP Lambert Academic Publishing Natural Agents Against Liver Death: Modulatory Effects of Natural Products Against Ethanol-Induced Hepatocyte Death

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