This volume examines the current state of free radical biology as it impacts on hepatic disorders. It takes a thorough look at the relationship of oxidative stress in acute and chronic disease and takes into account factors like: redox biomarkers; antioxidant defense and protection; cell signaling, mutations; oxidative damage involving lipids, proteins and nucleic acids; membrane trafficking, inflammation, mitochondrial dysfunction, alterations in immunological function and toxicology and hypoxia. Studies on Hepatic Disorders, the latest volume in the Oxidative Stress in Basic Research and Clinical Practice series, provides a comprehensive look at liver topics. It is organized into four sections, each one thoroughly covering its topic and consisting of chapters written by recognized field leaders. Section One, covers basic principles including redox signaling, antioxidant defenses, nitric oxide, oxidative mechanisms in senescence and regeneration and the detection of oxidative stress. Section Two, explores Pathophysiology. It ranges from cell damage to fibrogenic response as broken out in chapters on hepatocellular injury, mitochondrial damage, unfolded protein response and autophagy, inflammation, ischemia-reperfusion injury and finally, fibrogenesis. Sections Three and Four cover specific diseases and cancer, respectively. Most of the chapters focus on diseases including acute failure, alcoholic disease, viral hepatitis, iron overload, autoimmune disease, Wilson’s disease and more, while the chapters on cancer round out the book. From the Back Cover This volume examines the impact of free radical biology on hepatic disorders such as viral hepatitis, alcoholic disease, iron overload, and Wilson’s disease. It thoroughly explores the role of oxidative stress in acute and chronic disease, addressing factors such as redox biomarkers; antioxidant defense and protection; cell signaling; mutations; oxidative damage involving lipids, proteins, and nucleic acids; membrane trafficking; inflammation; mitochondrial dysfunction; alterations in immunological function; toxicology; and hypoxia. Its four sections, consisting of chapters by recognized field leaders, deal with basic principles of oxidation and hepatology, oxidative stress-related pathophysiology, oxidative stress and liver disease, and liver cancer. Intuitively structured and comprehensive, Studies on Hepatic Disorders is an invaluable addition to the Oxidative Stress in Applied Basic Research and Clinical Practice series and an essential resource for clinical hepatologists and researchers interested in the role of oxidative stress on liver function and disease. About the Author Emanuele Albano, MD, PhD received degrees in Medicine, Surgery and General Pathology from the University of Turin. He completed a PhD in Biochemistry from Brunel University of West London, Uxbridge, UK. He conducted research there as well as at the Departments of Biochemistry and Toxicology at the Karolinska Institute in Stockholm. He is currently Professor of General Pathology at the University of Eastern Piedmont "A. Avogadro" in Novara where he was formerly Director of the Department of Medical Sciences. Dr. Albano is a member of several European and international scientific societies, including the Society for Free Radical Research and the International Society for Biochemical Research on Alcoholism and serves on the editorial board and referees at several journals. His main fields of interest are the study of the molecular mechanisms of cell damage resulting from oxidation caused by free radicals with particular reference to changes in energy balance and ionic homeostasis of the liver including the involvement of free radicals in the pathogenesis of liver injury induced alcohol abuse. Maurizio Parola, MD, PhD, is Doctor of Biological Sciences, with a PhD in Experimental and Molecular Pathology, from the University of Turin and a PhD in Biochemistry
