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LAP Lambert Academic Publishing Molekulyarnyy polimorfizm prolaktina i beremennost': Prognosticheskaya rol' izmeneniy molekulyarnogo polimorfizma prolaktina vo vremya beremennosti

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Description

Izmenenie protsentnogo sootnosheniya izoform prolaktina, privodyashchee k formirovaniyu tak nazyvaemogo fenomena makroprolaktinemii diagnostiruetsya u beremennykh s chastotoy 10-46%. Pod fenomenom makroprolaktinemii podrazumevayut preobladanie v syvorotke krovi neaktivnykh fraktsiy vysokomolekulyarnykh form PRL – makro ili big-big-prolaktina, predstavlyayushchikh soboy kompleks Ig G s monomernym PRL molekulyarnoy massoy 23 kDa. Fenomen makroprolaktinemii bolee rasprostranen vo vremya beremennosti, chem u neberemennykh. Tsel' issledovaniya: izuchit' izmeneniya molekulyarnogo polimorfizma prolaktina (PRL) v zavisimosti ot osobennostey techeniya beremennosti i opredelit' ego prognosticheskuyu znachimost'. Issledovanie v syvorotke krovi beremennykh kontsentratsii prolaktina i makroprolaktina, a takzhe raschet ikh protsentnogo sootnosheniya pozvolyaet prognozirovat' techenie beremennostey vysokogo riska nevynashivaniya, ne orientiruyas' na standartnye laboratornye metodiki, v chastnosti – na kontsentratsiyu progesterona. Opredelenie molekulyarnogo polimorfizma prolaktina vo vremya beremennosti mozhno ispol'zovat' v kachestve diagnosticheskogo testa sostoyaniya sintsitiotrofoblasta.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
16 November 2012
Listed Since
06 February 2013

Barcode

No barcode data available

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