The Myc/Max/Mad Transcription Factor Network: 302 (Current Topics in Microbiology and Immunology, 302) - Image 1

Price loading...

Springer The Myc/Max/Mad Transcription Factor Network: 302 (Current Topics in Microbiology and Immunology, 302)

Name: The Myc/Max/Mad Transcription Factor Network: 302 (Current Topics in Microbiology and Immunology, 302)
Brand: Springer

Pathology

Price History & Forecast

No Price Data Available

Price history will appear here once data is collected from Amazon.

Price Distribution

No price data available for histogram

Description

Product Description Scientists often look askance at their colleagues whose research appears too strongly focused on a single gene or gene product. We are supposed to be interested in the “big picture” and excessive zeal in pursuit of a single pixel might seem to border on an obsession that is likely to yield only details. However as this volume of Current Topics in Microbiology and Immunology demonstrates, this is certainly not the case for myc. Intense study of this en- matic proto-oncogene over the last twenty years has only broadened our view of its functions and led to insights into mechanisms relating to transcriptional regulation as well as to cell growth, proliferation, differentiation, apoptosis and organismal development. The myc gene originally came to light as a retroviral oncogene (v-myc) associated with a wide range of acute neoplasms. It was later shown to be a virally transduced cellular gene (c-myc) which is a member of family of on- genes (c-myc,N-myc,L-myc). These family members are themselves subject to a bewildering assortment of genetic rearrangements associated with many different types of tumors derived from many different types of cells. These rearrangements (including chromosomal translocation, viral integration, and gene ampli?cation) act to uncouple expression of the myc family genes from their normal physiological regulators. The chapter by LIU and LEVENS - scribes the key pathways leading to regulation of myc expression, showing that such regulation occurs at several different levels and through multiple mechanisms. From the Back Cover Intense study of the enigmatic myc proto-oncogene over the last 20 years has broadened our view of its functions and led to insights into transcriptional regulation as well as cancer etiology, cell proliferation, apoptosis, and organismal development. How can one gene be involved in so many aspects of cellular behavior? Of particular interest is the fact that the Myc protein functions as part of a network (comprising Myc, Max, and Mad proteins) whose specific interactions direct transcriptional activation or repression of a large number of target genes. The chapters in this volume examine both molecular and biological aspects of the Myc/Max/Mad network. Included are contributions concerning the regulation of its expression, the mechanisms underlying its diverse transcriptional activities, the structural bases for its critical interactions, and the nature of its target genes. Other chapters explore the evolution of the network, its role in development and genomic instability, and the evidence for a parallel transcriptional network. Overall, this volume provides a broad and current overview of research on a crucial group of transcription factors.

Product Specifications

Brand: Springer
Format: Paperback
ASIN: 3642421415
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Other Branches of Medicine > Pathology
Domain: Amazon UK
Publication Date: 23 September 2014
Listed Since: 24 September 2014

Barcode

No barcode data available

Springer The Myc/Max/Mad Transcription Factor Network: 302 (Current Topics in Microbiology and Immunology, 302)

Price History & Forecast

No Price Data Available

Price Distribution

Description

Product Specifications

Barcode

Similar Products You Might Like

Microarrays and Transcription Networks (Molecular Biology Intelligence Unit)

Protein Complexes that Modify Chromatin: 274 (Current Topics in Microbiology and Immunology, 274)

Myb Transcription Factors: Their Role in Growth, Differentiation and Disease: 2 (Proteins and Cell Regulation, 2)

Myb Transcription Factors: Their Role in Growth, Differentiation and Disease: 2 (Proteins and Cell Regulation, 2)

Chromosomal Translocations and Oncogenic Transcription Factors: 220 (Current Topics in Microbiology and Immunology, 220)

Confocal Microscopy: Methods and Protocols: 122 (Methods in Molecular Biology, 122)

Fc Mediated Activity of Antibodies: Structural and Functional Diversity: 423 (Current Topics in Microbiology and Immunology, 423)

Negative Co-Receptors and Ligands: 350 (Current Topics in Microbiology and Immunology, 350)

Macrophages and Related Cells: 5 (Blood Cell Biochemistry, 5)

Prion Proteins: 305 (Topics in Current Chemistry, 305)

Mycorrhiza: State of the Art, Genetics and Molecular Biology, Eco-Function, Biotechnology, Eco-Physiology, Structure and Systematics

RNA Metabolism in Mitochondria: 34 (Nucleic Acids and Molecular Biology)

Genetics and Biotechnology: 2 (The Mycota, 2)

Tumor Suppressor Genes: Volume 2: Regulation, Function, and Medicinal Applications: 223 (Methods in Molecular Biology, 223)

Glycobiology and Medicine: Proceedings of the Sixth Jenner Glycobiology and Medicine Symposium, 14-17 September, 2002, Seillac, France: v. 535 (Advances in Experimental Medicine and Biology)

TOR: Target of Rapamycin: 279 (Current Topics in Microbiology and Immunology, 279)

MIF Family Cytokines in Innate Immunity and Homeostasis (Progress in Inflammation Research)

Lectin in Host Defense Against Microbial Infections: 1204 (Advances in Experimental Medicine and Biology, 1204)

Recent Advances on Model Hosts: 710 (Advances in Experimental Medicine and Biology, 710)

Recent Advances on Model Hosts: 710 (Advances in Experimental Medicine and Biology, 710)

C-Type Lectins in Immune Homeostasis: 429 (Current Topics in Microbiology and Immunology, 429)

Lectin in Host Defense Against Microbial Infections: 1204 (Advances in Experimental Medicine and Biology, 1204)

Fungal Physiology and Immunopathogenesis: 422 (Current Topics in Microbiology and Immunology, 422)

Advanced Technologies for Protein Complex Production and Characterization: 896 (Advances in Experimental Medicine and Biology, 896)