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VDM Verlag Un fosfato cálcico-silicato cálcico para la regeneración ósea: Caracterización y comportamiento

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Description

En el presente trabajo, se desarrolla una nueva línea de biomateriales para la regeneración ósea, basados en cementos de fosfato cálcico dopado con silicio mediante la sustitución iónica de grupos fosfato por grupos silicato. Como resultado de estas sustituciones, se logra la formación de una matriz con un tamaño medio de poro nanométrico, así como un aumento notable en su área de superficie. Estos cambios resultaron muy positivos para utilizar el biomaterial como matriz, para el transporte y liberación de distintos fármacos, obteniéndose una liberación lenta, controlada y constante del fármaco en el tiempo. In vivo se observó una buena interacción entre el hueso y el material, se obtuvo un cemento capaz de regular su grado de reabsorción en base a la cantidad de silicio incorporado. La regeneración ósea aumentó de forma estadísticamente significativa con aquellos cementos dopados con baja concentración de silicio.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
02 February 2015
Listed Since
27 February 2015

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