Woodhead Publishing Handbook of Cosmeceutical Excipients (Woodhead Publishing Series in Biomedicine)

Summary Cosmeceuticals are the latest additions to the health industry and have an ever-expanding market. They are considered to be a marriage between cosmetics and drugs and are defined as preparations applied on the body that may modify the physiological functions of the skin. However, as more cosmeceuticals are being launched in the market and more types of drugs are incorporated into the formulation, the composition of cosmeceuticals is becoming more complex. Handbook of Cosmeceutical Excipients and their Safeties summarises the current evidence relating to cosmeceuticals' side effects and highlights the important information that practitioners and consumers need to know, as well as ways to avoid the adverse effects of the excipients. Handbook of Cosmeceutical Excipients and their Safeties includes chapters covering topics such as the history of cosmeceuticals and the laws that regulate them, skin permeation, carcinogenicity as a systemic adverse effect and dermatitis as a topical adverse effect. It concludes with an appendix that gives brief information on the potency and permeability of common ingredients in cosmeceuticals. The appendix aims to highlight the maximum allowable quantity of each ingredient to ensure product safety for consumers. The appendix was prepared by compiling the ingredients of 257 products containing more than 500 compounds, collected from a hospital pharmacy in Singapore. About the Authors Kwan Yu Heng is from the Duke-NUS Graduate Medical School Singapore. Tung Yee Kei is from the National University of Singapore. Kochhar Jaspreet Singh is from the National University of Singapore. Ai-Ling Poh is a practising senior clinical pharmacist with the Department of Pharmacy, Parkway Hospitals Singapore Pte Ltd, Singapore. Kang Lifeng is from the National University of Singapore. Contents History and opportunities: Historical background of cosmeceuticals and its impact in current world; Concept of excipient safety: Who coined the term?; How big is the industry?; How many new products per year?; Law: Regulation in US and Role of US FDA in cosmeceuticals; Regulation in Europe; Regulation in ASEAN; A comparison of their differences; Skin permeation: Overview of the concept of flux; Translation of animal to human dose; Calculating of limits of excipients to prevent related adverse effects; Systemic effect: Cancer: Impact of carcinogenicity of excipients; Evidences available in current literature; Mechanism of carcinogenicity; Ways to prevent carcinogenicity of excipients. Local effect: Dermatitis: Impact of dermatitis of excipients; Evidences available in current literature; Mechanism of dermatitis; Prevention; Appendix: Brief description of each excipient.