Scion Publishing Glycobiology

This Glycobiology book is truly unique. Produced to commemorate the 80th birthday of Nathan Sharon, Glycobiology is an essential reference tool for anyone working in the field. Most research review volumes are narrowly focused. This book is different. It is a state-of-the-art fully comprehensive review volume covering a deliberately wide spectrum of work in this important field. With 28 chapters, covering over 350 pages, this title describes the latest research findings - from chemistry to biology and from pure science to industrial and medical applications. The book is written by world-class researchers and brings the reader fully up-to-date with the latest advances and forward thinking. All the major areas of glycobiology are covered including the synthesis of carbohydrates and glycoconjugates, their structural and functional analysis, carbohydrate binding proteins, carbohydrate modifying enzymes, and the applications of glycobiology research in medicine and industry. All active researchers in the glycosciences will value access to this important research compendium whether it be in the local library or in the lab. Contents SECTION 1. Introduction 1. Half a century at the carbohydrate-protein interface; 2. Glycobiology - discovery, diagnostics and drugs; SECTION 2. Synthesis of Carbohydrate and Glycoconjugates; 3. Sugar-lectin interactions: glycotargeting with synthetic glycoconjugates; 4. Recent developments in the synthesis and application of sialylmimetics; SECTION 3. Analysis and Structure; 5. Structure and function of the chondroitin/dermatan sulfates; 6. Revealing the hidden dimensions of glycosaminoglycans in solution and protein complexes with saccharide libraries, FTIR, and SRCD; 7. S tructural determination of N-linked glycans by matrix-assisted laser desorption/ionization and electrospray ionization mass spectrometry; 8. Integrated approach to glycan structure-function relationships; SECTION 4. Cell Biology of Carbohydrates and Glycoproteins; 9. Some observations on the biology of cell surface heparan sulfate proteoglycans; 10. Galectins: effective modulators of cytoskeletal organization and cellular growth - focus on galectin-8 as a model system; 11. Intracellular lectin involvement in glycoprotein maturation and quality control in the secretory pathway; SECTION 5. Carbohydrate-Binding Proteins; 12. The diversity of sialic acids and their interplay with lectins; 13. Structure and carbohydrate specificity of beta -p rism I fold lectins; 14. Protein-glycan interactions in immunoregulation: galectins as tuners of the inflammatory response; 15. Recognition of bacterial glycoepitopes by pulmonary C-type lectins as an arm of lung innate immunity; 16. Selectin and integrin recognition of ligands under shear flow: affinity and beyond; SECTION 6. Carbohydrate-Modifying Enzymes; 17. Complex carbohydrate-modifying enzymes; 18. Glycosyltransferases specific for the synthesis of mucin-type O-glycans; 19. Glycosylation in development; SECTION 7. Glycobiology and Medicine; 20. Glycobiology of mucins in the human gastrointestinal tract; 21. Mucosal glycoconjugates in inflammatory bowel disease and colon cancer; 22. Selectin-mediated metastasis of tumor cells: Alteration of carbohydrate-mediated cell-cell interactions in cancers induced by epigenetic silencing of glycogenes; 23. Glycosphingolipids in health and disease; 24. Pathogen-host interactions in Entamoeba histolytica; SECTION 8. Industrial Glycobiology; 25. The development of iminosugars as drugs; 26. Carbohydrate biosensors; 27. Glycoanalysis on a lectin array: applications to the development of biopharmaceuticals and life science research; 28. Lectin chips and CarboDeep '99: a rapid carbohydrate fingerprinting technology and its application for the food scientists; Afterword by Nathan Sharon.