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£105.13

Nova Science Publishers Inc Fanconi Anemia & Oxidative Stress: Mechanistic Background & Clinical Prospects

Name: Fanconi Anemia & Oxidative Stress: Mechanistic Background & Clinical Prospects
Brand: Nova Science Publishers Inc
Price: 105.13 GBP
Availability: InStock

Oncology

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Description

Fanconi Anemia (FA), a rare genetic disease featuring excess cancer risk and chromosomal instability, has received growing interest after the discovery that one of the defective genes in FA is associated with high-impact diseases such as familial breast cancer and ovary cancers. A well-documented relationship has accumulated in several decades and up to recently, studies have linked FA with a redox imbalance (oxidative stress, OS) in FA cells. The toxicity mechanisms of crosslinking agents (mitomycin C and diepoxybutane) in FA cells, along with the roles of OS-related aldehydes and glutathione in FA and in other diseases, are critically discussed. Also discussed is the proinflammatory state in FA phenotype. Additionally, recent studies have discovered an impairment in the structure and function of mitochondria in FA cell lines, while mitochondrial dysfunction in FA patients has so far been an unexplored field warranting ad hoc investigations. This book provides the readers with up-to-date information and perspectives on Fanconi anemia and oxidative stress that may prompt further elucidation of this intriguing disease, along with working hypotheses in clinical research and patients' management.

Product Specifications

Brand: Nova Science Publishers Inc
Format: hardcover
ASIN: 1634822978
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Internal Medicine > Diseases & Disorders > Oncology
Domain: Amazon UK
Release Date: 01 June 2015
Listed Since: 21 February 2015

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Nova Science Publishers Inc Fanconi Anemia & Oxidative Stress: Mechanistic Background & Clinical Prospects

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