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Nova Science Publishers Inc Histone Deacetylase Inhibitors (HDIs): Pharmacology, Uses & Health Effects

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Description

Histone deacetylase inhibitors (HDIs) are good anti-cancer targets. Histone acetyltransferases (HATs) and HDIs play opposite roles in the regulation of gene expression via an epigenetic mechanism. HATs catalyse the acetylation of lysine residues in histone tails, facilitating and sustaining gene transcription. HDIs remove the acetyl moieties from the epsilon-amine of lysine residues of histone tails, leading to a more condensed form of chromatin and preventing gene transcription. This book focuses on the use of HDIs for the treatment of lymphoid malignancies; myeloid malignancies; and breast cancer.

Product Specifications

Format
hardcover
Domain
Amazon UK
Release Date
01 June 2015
Listed Since
21 February 2015

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