Angiogenesis: Insights from a Systematic Overview (Cell Biology Research Progress)

This book provides an overview of the scientific methods used to search, analyse, appraise and synthesise studies on angiogenesis. It is intended to serve as a comprehensive piece of literature that encompasses all aspects from the molecular features of angiogenesis to the clinical value and potential pitfalls of angiogenic-based therapies. The primary motion to write this book is to provide an overview of the current status of the research in this field, with a focus on both tumoural and non-tumoural disease. Effects of various anti-angiogenic and pro-angiogenic molecules are also addressed in detail. This book comes at an important time in the development of so-called "translational medicine". Its purpose is to explain all the molecular bases underlying the angiogenic process and apply them to the clinical world. Reviewed and addressed are the basic concepts and importance of new drugs in clinical trials to inhibit or promote angiogenesis. This book may be considered as a scholarly reference work for libraries and researchers across the world and as a supplementary text for courses in medicine, physiology, biochemistry, molecular and cellular biology. It is expected that readers, both basic researchers and clinicians, will gain a good understanding of the essential value of angiogenesis in health and disease. About the Author Gaetano Santulli, MD, PhD is a physician-scientist. Cardiologist, he authored more than 100 publications in the field of cardiovascular medicine, including peer-reviewed research articles in high impact journals. He is currently working at Columbia University. He lives in Manhattan. Dr. Santulli's expertise comprises both clinical and basic research topics, including hypertension, diabetes, angiogenesis, myocardial infarction, heart failure, cardiac arrhythmias, and vascular disease. Furthermore, he has maintained an active clinical and research interest in metabolism and skeletal muscle disease. He is a member of several international academic societies, including American Heart Association (AHA), American Association for the Advancement of Science (AAAS), New York Academy of Sciences (NYAS), European Association of Heart Failure, European Association of Echocardiography, Acute Cardiovascular Care Association, European Association of Percutaneous Cardiovascular Interventions; European Society of Cardiology (ESC), Working Groups on: Hypertension & the Heart, Cardiac Cellular Electrophysiology, Myocardial Function, Cellular Biology of the Heart. He serves on the editorial boards of numerous medical Journals and he is Editor in Chief of the Journal of Cardiovascular Disease (JCvD).