Transforming Growth Factor-Beta in Cancer Therapy, Volume II: Cancer Treatment and Therapy (Cancer Drug Discovery and Development) - Image 1

£171.73

Humana Transforming Growth Factor-Beta in Cancer Therapy, Volume II: Cancer Treatment and Therapy (Cancer Drug Discovery and Development)

Name: Transforming Growth Factor-Beta in Cancer Therapy, Volume II: Cancer Treatment and Therapy (Cancer Drug Discovery and Development)
Brand: Humana
Price: 171.73 GBP
Availability: InStock

Oncology

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Description

Transforming Growth Factor-B in Cancer Therapy, Volume II: Cancer Treatment and Therapy The chapters in this volume confer an abundance of knowledge about the current state ofour understanding oftransforming growth factor-B (TGF-B) in cancer treatment and therapy. Unlike several more traditional positive polypeptide growth factors that stim ulate cellular proliferation, the prototypical TGF-B is now known to inhibit the growth of most normal cell types, including those of epithelial and mesenchymal origin. However, there are examplesofcell types that can be stimulated by TGF-B under certain conditions. TGF-B also induces the accumulation of matrix molecules by stimulating their synthesis as well as inhibiting their degradation. Moreover, TGF-B induces apoptosis of certain cell types, thereby restricting their proliferation. OveractivityofTGF-~ has been linked to several diseases. For instance, the effect ofTGF-~ on matrix accumulation contributes to fibrotic conditions, like glomerulonephritis, lung fibrosis and liver cirrhosis (1). TGF-~ has a very complicated role in cancer that is only beginning to be understood.

Product Specifications

Brand: Humana
Format: paperback
ASIN: 1617377368
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Internal Medicine > Diseases & Disorders > Oncology
Domain: Amazon UK
Release Date: 19 November 2010
Listed Since: 01 October 2010

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Humana Transforming Growth Factor-Beta in Cancer Therapy, Volume II: Cancer Treatment and Therapy (Cancer Drug Discovery and Development)

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