Thyroid Hormone Disruption and Neurodevelopment (Contemporary Clinical Neuroscience) - Image 1

£123.68

Springer Thyroid Hormone Disruption and Neurodevelopment (Contemporary Clinical Neuroscience)

Name: Thyroid Hormone Disruption and Neurodevelopment (Contemporary Clinical Neuroscience)
Brand: Springer
Price: 122.39 GBP
Availability: InStock

Endocrinology

Price History & Forecast

Last 40 days • 40 data points (No recent data available)

Historical

Generating forecast...

Price Distribution

Price distribution over 40 days • 3 price levels

Days at Price

Current Price

Price Analysis

Most common price: £122 (27 days, 67.5%)

Price range: £120 - £124

Price levels: 3 different prices over 40 days

Description

Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under various pathological conditions. In addition, environmental factors including endocrine-disrupting chemicals and bacterial endotoxins may disrupt thyroid hormone action in brain, causing abnormal brain development and functional disruption. This is a first book to comprehensively describe the effect of thyroid hormone disruption in the central nervous system. The first section deals with the disruption of thyroid hormone action at the molecular level. First the authors provide a summary of the possible molecular mechanisms of thyroid hormone action in the brain, then they discuss several factors that may disrupt thyroid hormone action. In the second section, animal models to study thyroid hormone action will be introduced. An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a “repressor” of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals. Thus, several different kind of animal models may be used to clarify the role of thyroid hormone and its receptor in the brain. In the third section, human studies on thyroid disease and neurodevelopment will be introduced. Although endemic cretinism induced by iodine deficiency and sporadic cretinism by various thyroid mutation are well known, the pathophysiological mechanisms that create each abnormal phenotype are not fully understood.

Product Specifications

Brand: Springer
Format: Paperback
ASIN: 1493981242
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Internal Medicine > Endocrinology
Domain: Amazon UK
Release Date: 27 June 2018
Listed Since: 01 July 2018

Barcode

No barcode data available

Springer Thyroid Hormone Disruption and Neurodevelopment (Contemporary Clinical Neuroscience)

Price History & Forecast

Price Distribution

Price Analysis

Description

Product Specifications

Barcode

Similar Products You Might Like

Thyroid Hormone Disruption and Neurodevelopment (Contemporary Clinical Neuroscience)

Thyroid Diseases

Thyroid Hormone Nuclear Receptor: Methods and Protocols: 1801 (Methods in Molecular Biology, 1801)

Thyroid Hormones: Functions, Related Diseases & Uses (Endocrinology Research & Clinical Developments Series)

Thyroid Function Testing: 28 (Endocrine Updates, 28)

Growth Hormone Deficiency: Physiology and Clinical Management

Comprehensive Handbook of Iodine: Nutritional, Biochemical, Pathological and Therapeutic Aspects

Handbook of Neuroendocrinology

Springer - Thyroid and Heart Failure: Pathophysiology to Clinics

Neurotoxin Modeling of Brain Disorders ― Life-long Outcomes in Behavioral Teratology: 29 (Current Topics in Behavioral Neurosciences, 29)

Gene Engineering in Endocrinology: 22 (Contemporary Endocrinology)

Recent Advances in Transthyretin Evolution, Structure and Biological Functions

Clinical Neuroembryology: Development and Developmental Disorders of the Human Central Nervous System

Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors

Thyroid Diseases: Clinical Fundamentals and Therapy

Neuroendocrinology of Mood: 8 (Current Topics in Neuroendocrinology, 8)

Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders: Novel Strategies for Research and Treatment

Developmental Neuroendocrinology: 9 (Masterclass in Neuroendocrinology, 9)

Academic Press - Molecular Mechanisms of Hormone Actions on Behavior

Receptors in the Developing Nervous System: Volume 1 Growth factors and hormones

Trace Elements in Brain Health and Diseases (Nutritional Neurosciences)

Thyroid Disease in Adults

Humana Thyroid Hormone Nuclear Receptor Methods and Protocols 1801

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability