Springer Good Cascade Impactor Practices, AIM and EDA for Orally Inhaled Products

Offering a simpler way to interpret aerosol particle size data from orally inhaled products, this book describes mutually-independent efficient data analysis (EDA) metrics that can be derived from full resolution or abbreviated impactor measurements (AIM). From the Back Cover Aerodynamic particle size characteristics of orally inhaled products (OIPs) are critical to their performance.  Testing based on cascade impaction has been the primary tool used to characterize this critical quality attribute and is a regulatory expectation for Quality Control purposes.  In recent years, there have been substantial efforts directed at improving aerodynamic particle size determinations.   Good Cascade Impactor Practices, AIM and EDA for Orally Inhaled Products brings together for the first time a review of best practices for performing cascade impactor testing with a thorough discussion of the recently introduced concepts of abbreviated impactor measurements (AIM) and efficient data analysis (EDA).     Topics covered include:   ·         Review of pharmacopeial methods (US and European) for assessment of aerodynamic particle size distribution (APSD) of OIPs. ·         Physical processes that underlie aerosol formation from OIPs and the mechanisms that affect the APSD. ·         Good cascade impactor practice (GCIP) related to either full resolution or abbreviated impactor measurements.  ·         Introduction of the AIM and EDA concepts. ·         Selection of the type of testing through the development lifecycle of an OIP. ·         Theoretical basis for EDA. ·         Performance evaluation of EDA as a quality control element. ·         Case studies related to the application of  EDA.  ·         Experimental studies validating the AIM concept conducted by European Pharmaceutical Aerosol Group (EPAG) and the Cascade Impaction Working Group of the International Pharmaceutical Aerosol Consortium on Regulation and Science (IPAC-RS).  ·         Regulatory and compendial pathways to adoption of AIM and EDA. ·         Exploration and extension of AIM as a potential approach to measures that could be more predictive of particle deposition in the human respiratory tract.   This comprehensive volume was written by a group of prominent international experts in aerosol testing led by members of the Cascade Impaction Working Group of IPAC-RS.  IPAC-RS is an international association of pharmaceutical companies committed to advancing consensus-based, scientifically driven standards and regulations for orally inhaled and nasal drug products. About the Author Terrence P. Tougas, Ph.D. Terrence Tougas, Ph.D. is a Highly Distinguished Research Fellow in Analytical Development at Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT where he has over 20 years of experience and currently heads the Stability, Submission Documents and Information Systems Group. He contributed to chemistry, manufacturing and controls sections of several New Drug Applications, including for pulmonary (metered dose inhalers, inhalation solutions and nasal sprays) and antiviral products. Dr. Tougas is a member and past chair of the International Pharmaceutical Aerosol Consortium on Regulation and Science (IPAC-RS) Board of Directors, and has been leader or member of several IPAC-RS working groups. Dr. Tougas served on the Steering Committee and chaired the Drug Product Technical Committee of the Product Quality Research Institute (PQRI). More recently, he helped form the International Consortium on Innovation and Quality in Pharmaceutical Development (IQ), served as the first chair of its Board of Directors and is a member of the IQ Statistics Leadership Group. Dr. Tougas authored numerous publications related to the CMC aspects of drug development, analytical chemistry and quality control statistics. He contributed chapters to books on chromatography and leachables/extractables testing of inhalation products. His background