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CRC Press Revival: Principles of Animal Extrapolation (1991) (CRC Press Revivals)

Name: Revival: Principles of Animal Extrapolation (1991) (CRC Press Revivals)
Brand: CRC Press

General Medical Issues

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Product Description Principles of Animal Extrapolation addresses the conceptual basis for animal extrapolation and provides an abundance of documentation that illustrates how these principles may be applied in the selection of the more appropriate models and in the interpretation of toxicological studies. The book analyzes and documents each specific biological cause of interspecies differences in susceptibility to toxic agents, including differences in absorption, gut flora, tissue distribution, metabolism, mechanisms and efficiencies of repair, and excretion. The problem of the heterogenicity of the human population is addressed through several chapters that assess the availability and prospects of developing predictive animal models for normal humans, as well as selected potential high-risk groups. Other topics presented in this book include the biological basis of regulatory actions involving attempts to extrapolate from exceptionally high exposure levels to realistic values, especially carcinogens; an assessment of genotoxicity tests, their ability to predict carcinogenicity in whole animals, and the manner in which they should be used by regulatory agencies; birth defects; and predicting the risk of human teratogenesis. Principle of Animal Extrapolation is essential for environmental toxicologists. It also provides valuable information to biomedical scientists (especially those involved in drug development and testing) and regulatory personnel in agencies such as the EPA, the OSHA, the NIOSH, and the FDA. About the Author Edward J. Calabrese is a board certified toxicologist who is Professor of Toxicology at the University of Massachusetts School of Pubic Health, Amherst. Dr. Calabrese has researched extensively in the area of host factors affecting susceptibility to pollutants and is the author off more than 300 papers in scholarly journals, as well as 12 books.

Product Specifications

Brand: CRC Press
Format: hardcover
ASIN: 1138505870
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > General Medical Issues
Domain: Amazon UK
Release Date: 20 September 2017
Listed Since: 08 December 2017

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CRC Press Revival: Principles of Animal Extrapolation (1991) (CRC Press Revivals)

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