CRC Press Stem Cell Therapy for Neurodegenerative Disorders: Mechanisms, Applications, and Advances

This book comprehensively reviews the role of stem cell therapy against various neurodegenerative disorders. The initial chapters present different neurodegenerative disorders and discuss the application of stem cell therapy for Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and Huntington's disease. Aging and its impact on neurodegenerative disorders are also covered, addressing neuronal dysfunctions with age, neuromuscular dysfunctions like sarcopenia and frailty, and the potential role of stem cell interventions in aging. The subsequent section provides an overview of the different types of therapies, including cell replacement and neuroprotection. It also covers clinical trials of stem cell therapies for neurodegenerative disorders and discusses the advantages and disadvantages of various stem cell types and delivery methods. Further, the book explores the mechanisms of action, detailing how stem cells induce neural regeneration and repair. It also examines their role in reducing inflammation and oxidative stress, alongside potential risks and safety concerns associated with stem cell therapies. Toward the end, the book presents advanced delivery systems for stem cell therapies, the therapeutic potential of stem cell-derived exosomes and microvesicles in neurodegeneration, preclinical studies in animal models, and the role of organoids in neurodegenerative disorders. This book is useful for researchers and students of neuroscience, neurology, stem cells, pharmaceutical sciences, and biotechnology. Key Features: Provides an in-depth review of stem cell therapy for various neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, ALS, and Huntington's disease Addresses aging-related neuronal and neuromuscular dysfunctions, such as sarcopenia and frailty Offers a detailed analysis of different types of stem cell-based therapies, including cell replacement and neuroprotection Covers clinical trials of stem cell therapies for neurodegenerative disorders, discussing the advantages and disadvantages of various stem cell types Explores the mechanisms by which stem cells promote neural regeneration and repair and reduce inflammation and oxidative stress Discusses cutting-edge delivery systems for stem cell therapies, enhancing the effectiveness and precision of treatments This book is useful for researchers and students of neuroscience, neurology, stem cells, pharmaceutical sciences, and biotechnology.