Hybrid Frequentist/Bayesian Power and Bayesian Power in Planning Clinical Trials (Chapman & Hall/CRC Biostatistics Series) - Image 1

£93.83

CRC Press Hybrid Frequentist/Bayesian Power and Bayesian Power in Planning Clinical Trials (Chapman & Hall/CRC Biostatistics Series)

Name: Hybrid Frequentist/Bayesian Power and Bayesian Power in Planning Clinical Trials (Chapman & Hall/CRC Biostatistics Series)
Brand: CRC Press
Price: 93.83 GBP
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Public Health

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Description

Hybrid Frequentist/Bayesian Power and Bayesian Power in Planning Clinical Trials provides a practical introduction to unconditional approaches to planning randomised clinical trials, particularly aimed at drug development in the pharmaceutical industry. This book is aimed at providing guidance to practitioners in using average power, assurance and related concepts. This book brings together recent research and sets them in a consistent framework and provides a fresh insight into how such methods can be used. Features: A focuson normal theory linking average power, expected power, predictive power, assurance, conditional Bayesian power and Bayesian power. Extensions of the concepts to binomial, and time-to-event outcomes and non-inferiority trials An investigation into the upper bound on average power, assurance and Bayesian power based on the prior probability of a positive treatment effect Application of assurance to a series of trials in a development program and an introduction of the assurance of an individual trial conditional on the positive outcome of an earlier trial in the program, or to the successful outcome of an interim analysis Prior distribution of power and sample size Extension of the basic approach to proof-of-concept trials with dual success criteria Investigation of the connection betweenconditional and predictive power at an interim analysis and power and assurance Introduction of the idea of surety in sample sizing of clinical trials based on the width of the confidence intervals for the treatment effect, and an unconditional version.

Product Specifications

Brand: CRC Press
Format: hardcover
ASIN: 1032111291
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > General Medical Issues > Public Health
Domain: Amazon UK
Release Date: 20 June 2022
Listed Since: 27 November 2021

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CRC Press Hybrid Frequentist/Bayesian Power and Bayesian Power in Planning Clinical Trials (Chapman & Hall/CRC Biostatistics Series)

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