Group Sequential and Adaptive Methods for Clinical Trials (Chapman & Hall/CRC Biostatistics Series) - Image 1

£81.80

Chapman and Hall/CRC Group Sequential and Adaptive Methods for Clinical Trials (Chapman & Hall/CRC Biostatistics Series)

Name: Group Sequential and Adaptive Methods for Clinical Trials (Chapman & Hall/CRC Biostatistics Series)
Brand: Chapman and Hall/CRC
Price: 81.64 GBP
Availability: InStock

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Description

In clinical trials, monitoring accumulating data at regular intervals is essential for balancing ethical and financial considerations against scientific rigor. This comprehensive second edition reflects the remarkable evolution in adaptive clinical trial methodology over the past two decades. Since publication of the first edition, these approaches have transformed from theoretical concepts to widely accepted practices, now endorsed by regulatory authorities, including formal FDA guidance. Features: Eleven entirely new chapters, including optimal design construction, delayed "pipeline" data accommodation, and multiple comparison procedures Eight dedicated chapters on adaptive methods including sample size re-assessment, seamless Phase II/III trials, multi-arm multi-stage trials, and enrichment designs Exact methods for binary and Poisson data with applications to vaccine trials Expanded discussion of binding versus non-binding futility boundaries for enhanced decision-making A chapter with a thoroughly updated review of Bayesian approaches to sequential trial design and analysis Incorporates response-adaptive treatment assignment in group sequential designs Practical computational methods and software guidance for implementing the techniques This definitive resource serves statisticians, clinical researchers, pharmaceutical scientists, and regulatory professionals involved in clinical trial design and analysis. The text balances theoretical foundations with practical implementation guidance, making it invaluable for both experienced practitioners and those new to adaptive trial methodology. With twice the content of the first edition, this volume provides the comprehensive understanding needed to design more efficient, ethical, and scientifically rigorous clinical trials, ultimately accelerating the delivery of effective treatments to patients.

Product Specifications

Brand: Chapman and Hall/CRC
Format: hardcover
ASIN: 1584888474
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > General Medical Issues > Public Health
Domain: Amazon UK
Release Date: 08 December 2025
Listed Since: 12 December 2006

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Chapman and Hall/CRC Group Sequential and Adaptive Methods for Clinical Trials (Chapman & Hall/CRC Biostatistics Series)

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