Wiley Kinase Inhibitor Drugs (Wiley Series in Drug Discovery and Development)

Review "In conclusion, I strongly recommend this book to anyone who is interested and new to the field of kinase inhibitors. Indeed, I believe this book should not merely sit on the shelves of kinase experts, but should be used frequently for reference." (ChemMedChem, 2010) "Delivers what the title promises: a comprehensive treatment of drugs that inhibit kinases. ... Will be interesting to any chemist or biologist desiring a behind-the-scenes look at modern strategies of drug discovery and their practical applications to some challenging targets." (Journal of Medicinal Chemistry, April 2010) Product Description A comprehensive resource on case studies of marketed kinase drugs and promising drug trialsSince the discovery of protein kinase activity in 1954, the field of protein kinase drug discovery has advanced dramatically. With the ongoing clinical success of the Bcr-Abl kinase inhibitor Gleevec in the treatment of chronic myelogenous leukemia and seven additional marketed kinase inhibitor drugs, researchers have compelling evidence that kinase inhibitors can be highly efficacious in the treatment of diseases caused by aberrant activity of protein kinase. Currently more than 100 protein kinase inhibitors are in clinical development.In one comprehensive volume, the editors, Dr. Rongshi Li and Dr. Jeffrey Stafford, present timely and important case studies of marketed kinase drugs and several of the most advanced kinase inhibitors in clinical trials. Kinase Inhibitor Drugs includes:Case studies from leading investigators and experts in the field that provide firsthand accounts of kinase inhibitor discoveryCurrent thinking on kinase structure, biochemistry, and signal transduction pathwaysInformation on state-of-the-art technologies and tools such as structure-based and fragment-based drug discoveryA lineup of clinical-phase growth factor receptor inhibitorsInhibitors of cell cycle kinasesThe discovery of allosteric inhibitors of MEK kinaseInformation on pharmacogenomics and its application to kinase inhibitor clinical development From the Inside Flap A comprehensive resource on case studies of marketed kinase drugs and promising drug trialsSince the discovery of protein kinase activity in 1954, the field of protein kinase drug discovery has advanced dramatically. With the ongoing clinical success of the Bcr-Abl kinase inhibitor Gleevec in the treatment of chronic myelogenous leukemia and seven additional marketed kinase inhibitor drugs, researchers have compelling evidence that kinase inhibitors can be highly efficacious in the treatment of diseases caused by aberrant activity of protein kinase. Currently more than 100 protein kinase inhibitors are in clinical development.In one comprehensive volume, the editors, Dr. Rongshi Li and Dr. Jeffrey Stafford, present timely and important case studies of marketed kinase drugs and several of the most advanced kinase inhibitors in clinical trials. Kinase Inhibitor Drugs includes:Case studies from leading investigators and experts in the field that provide firsthand accounts of kinase inhibitor discoveryCurrent thinking on kinase structure, biochemistry, and signal transduction pathwaysInformation on state-of-the-art technologies and tools such as structure-based and fragment-based drug discoveryA lineup of clinical-phase growth factor receptor inhibitorsInhibitors of cell cycle kinasesThe discovery of allosteric inhibitors of MEK kinaseInformation on pharmacogenomics and its application to kinase inhibitor clinical development From the Back Cover A comprehensive resource on case studies of marketed kinase drugs and promising drug trialsSince the discovery of protein kinase activity in 1954, the field of protein kinase drug discovery has advanced dramatically. With the ongoing clinical success of the Bcr-Abl kinase inhibitor Gleevec in the treatment of chronic myelogenous leukemia and seven additional marketed kinase inhibitor drugs, researchers have