Academic Press Prokineticins: From the Gastrointestinal Tract to Neuroinflammation (Molecular Mediators in Health and Disease: How Cells Communicate)

Prokineticins: From the Gastrointestinal Tract to Neuroinflammation explores the intricate biology and pathophysiological roles of prokineticin peptides, from developmental processes in the heart and brain to the regulation of homeostasis in health and disease. Beginning with an introduction to prokineticins, the book moves on to discuss physiological functions across the human body, including the regulation of circadian rhythm, food intake, heart and kidney function and the reproductive system. Chapters then cover the prokineticin system in neurogenesis dysfunction, obesity and diabetes, reproductive system disorders and cardiovascular diseases. The prokinetcin system is also explored in the context of neurodegenerative disease and traumatic brain injury, pain, inflammation, infection and cancer. It also investigates natural and pharmacological inhibitors of PK receptors and closes with a look towards future research perspectives. Explores the diverse physiological roles of prokineticins in neurogenesis, circadian rhythm, reproduction, and cardiovascular function Investigates the pathophysiological implications of altered prokineticin expression in diseases, including cancer, diabetes, and neurodegenerative disorders Highlights the therapeutic potential of prokineticin receptors as targets for treating cardiovascular, metabolic, and nervous system conditions Provides comprehensive analyses of endogenous peptides, synthetic ligands, and modulators of prokineticin receptors in preclinical models Serves as an essential resource for biologists, clinicians, and students, bridging gaps in understanding PKs across various fields