Elsevier Necroptosis: A Programmed Cell Death Machinery in Human Health

Necroptosis: A Programmed Cell Death Machinery in Human Health provides a comprehensive review of the evolving concepts of programmed cell death (PCD) machinery. The book traces the evolutionary origin of necroptosis, necroptotic proteins, and how the proteins contribute to necroptosis and other cell death pathways. It clarifies necroptosis as more than merely an alternate to extrinsic apoptosis but explores it as an inflammatory form of cell death interconnected with multiple death signaling that ultimately dictates physiological outcome. Coverage summarizes the role of the death pathway and proteins in mammalian health and disease as well as key diseases where they play contributing roles. The involvement of necroptosis in pulmonary diseases including activation during SARS-CoV2 infection is covered along with other gastroenteric diseases, cancer, and aging. Beyond conveying clinical knowledge, these topics will be of strong research interest to the biomedical bench scientist. Explains programmed cell death machinery as ubiquitous in all eukaryotes and as fundamentally related to health and disease in mammals Elucidates necroptosis as a factor of tissue injury in high relevant human diseases, including COVID-19 Explains the suppression of necroptosis and other cell death pathways as a key modus operandi by pathogens