Elsevier Supercritical Fluids in Pharmaceutical and Biomedical Technologies: From Controlled Drug Release Formulation to Tissue Engineering

Supercritical Fluids in Pharmaceutical and Biomedical Technologies: From Controlled Drug Release Formulation to Tissue Engineering describes the well-studied, but previously not well summarised supercritical fluid technologies useful for pharmaceutical and biomedical applications. Supercritical technologies have been described over the last 20 years as innovative and capable of solving many problems relating to conventional chemical processes such as extraction, crystallization, foaming, drying precipitation, aerogels fabrications. This is generally true but there remain exceptions and limitations. Featuring extensive case studies and examples presenting from lab-scale to industrial scale, the author highlights the innovations of the described processes, but also their drawbacks, such as the difficulties to generalize the process application to several drugs and biomolecules. The book provides a critical overview on the necessity of process optimization case-by case that have limited the use of these dense gases in larger scale pharmaceutical or biomedical industrial production. Supercritical Fluids in Pharmaceutical and Biomedical Technologies: From Controlled Drug Release Formulation to Tissue Engineering will appeal to graduate and postdoc level students and researchers primarily in chemistry, pharmaceutical chemistry, and chemical engineering. R&D scientists at pharma and biotech companies and postdoc students studying advanced pharmaceutical technologies for drug delivery and tissue engineering, medical biomedical technology and bioengineering will also find the book useful for reference. Provides a much-needed summary and overview of the use of supercritical fluids in pharmaceutical and biomedical applications Addresses both the successes and limitations in application of supercritical fluids in this area Presents several schematic descriptions of supercritical fluid-based processes. Features a range of pharmaceutical and biomedical case studies and examples from lab-scale to industrial scale, assessing successes and limitations Provides a critical overview on the necessities of process optimization case-by case that have limited the use of dense gases in larger scale pharmaceutical or biomedical industrial production