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£49.83

CRC Press The Charnoly Body: A Novel Biomarker of Mitochondrial Bioenergetics

Name: The Charnoly Body: A Novel Biomarker of Mitochondrial Bioenergetics
Brand: CRC Press
Price: 49.83 GBP
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Pharmacology

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Description

Diversified physicochemical injuries trigger Charnoly body (CB) formation as pleomorphic, electron-dense, multi-lamellar stacks of nonfunctional mitochondrial membranes in the most vulnerable cell. Free radicals induce downregulation of mitochondrial DNA, microRNA, AgNOR, and epigenetics to trigger CB molecular pathogenesis. CB is eliminated by energy (ATP)-driven lysosome-dependent charnolophagy as a basic molecular mechanism of intracellular detoxification to prevent acute and chronic diseases. Accumulation of CB at the junction of axon hillock and charnolosome (CS) at the synapses causes cognitive impairments; whereas, nonspecific induction of CB causes GIT stress, myelosuppression, alopecia, neurotoxicity, cardiotoxicity, and infertility in multidrug-resistant malignancies. Hence, stem cell-specific CB, charnolophagy, and CS agonists/antagonists are introduced as novel charnolopharmacotherapeutics for the successful treatment of cardiovascular diseases, neurodegenerative diseases, infectious diseases, drug addiction, and cancer. Nanoparticles to improve drug delivery, CS exocytosis, and disease-specific spatiotemporal charnolosomics employing correlative and combinatorial bioinformatics boost mitochondrial bioenergetics through balanced diet, exercise, and antioxidants. The book will be of interest to medical scientists and practitioners. About the Author Dr Sushil Sharma is a Professor and Course Director of Pharmacology at the Saint James School of Medicine in Saint Vincent & Grenadines. He received Ph.D. in Neuropharmacology from A.I.IM.S, New Delhi; Radiopharmaceutical Trainings from BARC, Bombay, GE, Siemens, Agilent Technologies, & Cardinal Health in the U.S. He has organized and chaired several world conferences, has been awarded 5 gold medals, a certificate of honor at I.T Nano-2014 Conference, Boston. (Original Discoveries: Electromicroinjector; Charnoly Body in Purkinje Neurons, IL-10 Receptors on Cortical Neurons, & MTs-Gene-Manipulated Mice), and authored 235 publications.

Product Specifications

Brand: CRC Press
Format: paperback
ASIN: 0367780291
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Other Branches of Medicine > Pharmacology
Domain: Amazon UK
Release Date: 31 March 2021
Listed Since: 15 December 2020

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CRC Press The Charnoly Body: A Novel Biomarker of Mitochondrial Bioenergetics

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